MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS

新生儿重症监护病房的多中心网络

• 批准号: 6895896
• 负责人: DALE L. PHELPS
• 金额: $ 77.65万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6895896
• 关键词: clinical trials; cooperative study; disease /disorder proneness /risk; health care facility information system; human subject; human therapy evaluation; low birth weight infant human; mother /infant health care; neonatal intensive care; newborn human (0-6 weeks); obstetrics; patient oriented research; pediatric nursing; pediatrics; perinatal; pregnancy disorder; premature infant human; prenatal care; prenatal diagnosis

DESCRIPTION: (Provided by Applicant) The University of Rochester proposes to participate in the NICHD Collaborative Neonatal Research Network This Network was formed 15 years ago to develop reliable scientific evidence for best clinical practice. By combining the populations of many intensive units, sufficient sample sizes of adequate diversity are enrolled in a reasonable time frame. The Network also collects prospective observational data for pilot projects, calculating sample sizes, and identification of key issues for future studies. Efforts are coordinated with a parallel Maternal-Fetal Medicine Network, and success and productivity relies on the creativity, design skills, experience and dedicated work of the center principal investigators that make up the Steering Committees, and the dedicated research staff that conduct the trials and collect the data. Dale L. Phelps brings a wealth of personal experience in designing and conducting neonatal multi-center randomized trials. In addition, the other 10 academic faculty have also been conducting multi-center randomized trials and basic research for 18+ years, while caring for the 1200 NICU admissions annually. They work closely with the Maternal-Fetal Medicine Division as the Regional Perinatal Center with established maternal transport of known high risk pregnancies, ensuring a stable population for recruitment. The NICU Follow-up Program evaluates all NICU graduates meeting high risk criteria (-20%), plus all infants in research protocols. In addition, all NICU graduates (high risk or not) are tracked via mailed annual questionnaires to families and physicians through age 5 years. Over 93% follow up has been accomplished for enrolled research subjects in follow up studies to date. The Children?s Hospital at Strong Perinatal Center at the University of Rochester has a large diverse neonatal population, experienced investigative faculty, and an outstanding Medical Research Institute. This center will be an outstanding participating Network Center. Dale Phelps as the PI, will be a dedicated participant and contributor on the Steering Committee and working subcommittees.

描述：（由申请人提供）罗切斯特大学提议 参加NICHD合作新生儿研究网络该网络 是在15年前成立的，目的是为了开发可靠的科学证据以获得最佳 临床实践。通过将许多密集型单位的种群结合在一起， 足够的足够多样性样本量被纳入合理 大体时间。该网络还收集了试点的预期观察数据 项目，计算样本量以及确定关键问题 未来的研究。努力与平行的母亲协调 医学网络以及成功和生产力取决于创造力， 中心校长的设计技能，经验和专门工作 组成指导委员会和专门研究的调查人员 进行试验并收集数据的员工。 戴尔·菲尔普斯（Dale L. Phelps）为设计和 进行新生儿多中心随机试验。另外，其他10 学术教师还一直在进行多中心随机试验和 18年以上的基础研究，照顾1200 NICU入学 每年。他们与母亲养育医学部紧密合作 区域围产期中心拥有已知高的孕产妇运输 风险怀孕，确保稳定的招募人口。 NICU 后续计划评估所有符合高风险标准的NICU毕业生（-20％）， 加上研究方案中的所有婴儿。此外，所有NICU毕业生 （是否高风险）通过邮寄的年度问卷跟踪给家庭 和医生在5岁时。超过93％的随访已完成 迄今为止，在后续研究中接受的研究对象。 儿童医院在大学强的围产期中心 罗切斯特的新生儿种群大量不同，经历了调查 教师和一家杰出的医学研究所。这个中心将是一个 出色的参与网络中心。戴尔·菲尔普斯（Dale Phelps）作为pi，将是 专门的参与者和指导委员会撰稿人和工作 小组委员会。