RESIN-BASED REMINERALIZING CEMENTS AND COMPOSITES

树脂基再矿化水泥和复合材料

• 批准号: 6924317
• 负责人: SABINE H DICKENS
• 金额: $ 28.5万
• 依托单位: AMERICAN DENTAL ASSOCIATION FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-15 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6924317
• 关键词: biodegradable product; biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; calcium phosphate; clinical research; clinical trials; composite resins; dental adhesive /sealant; dental bonding material; dental caries; dental caries inhibitor; dental materials; human subject; human therapy evaluation; human tissue; odontoblasts; patient oriented research; polymethacrylate; preventive dentistry; restorative dentistry; tissue /cell culture; tooth enamel

DESCRIPTION: The goals are to develop resin-based remineralizing materials for improved prevention and treatment of caries, one of the most prevalent oral diseases often recurring after restorative treatment and occurring as root caries in the elderly. A more conservative treatment of caries known as atraumatic restorative treatment (ART), to which these materials could be applied, has recently become popular. Here, resin-based bioactive composites containing calcium phosphate (Ca-PO4) fillers for the release of Ca and P04 ions and, where applicable, fibers or whiskers for reinforcement are developed for the remineralization treatment of hypersensitivity and various caries-related diseases, e.g., the prevention of recurrent caries. The composites contain acidic- and other methacrylate resins, Ca-PO4 fillers and, if indicated fluoride additives. The basic composition is closely related to those described in previously funded work, which led to a highly biocompatible cement with excellent results when used as a remineralizing agent for in vitro generated tooth lesions and as a direct pulp-capping agent in vivo. Hypothesis: Existing resin-based bioactive composites and cements can be modified for applications, where remineralizing and caries preventive capabilities are of greatest importance. Specific Aims: 1. Develop and test in vitro and in situ formulations specifically tailored to ART by adjusting the viscosity of current cements while maintaining high Ca and PO4 ion release, remineralization potential and greater strength than glass ionomer cements; 2. Develop a remineralizing root caries restorative material; 3. Develop a slow-release biodegradable coating for hypersensitive teeth, caries repair, and prevention; 4. Formulate remineralizing orthodontic and crown and bridge cements and study the enamel protection from the orthodontic cement in a clinical trial. Completion of this research will lead to Ca- PO4 cements and composites with improved adhesion to dentin and improved strength for ART and the treatment of root caries.

描述：目标是开发基于树脂的回忆材料，以改善龋齿的预防和治疗，这是恢复性治疗后最普遍的口腔疾病之一，并且是老年人的根龋齿。对这些材料可以应用的性行性修复治疗（ART）的龋齿的更保守的治疗方法最近变得流行。 在这里，基于树脂的生物活性复合材料含有磷酸钙（CA-PO4）填充剂，用于释放Ca和P04离子，并且在适用的情况下，开发了用于增强培养基的纤维或晶须，以回忆性高敏性和各种龋齿相关疾病的治疗，例如，相关性疾病的预防是复发的预防。复合材料含有酸性和其他甲基丙烯酸酯树脂，Ca-Po4填充剂以及（如果指示为氟化物添加剂）。基本组成与先前资助的工作中描述的基本组成密切相关，这导致了高度生物相容性的水泥，当用作体外产生的牙齿病变的回忆剂时，并作为体内的直接纸浆封面剂。假设：现有的基于树脂的生物活性复合材料和水泥可以在应用程序中修改，在这种应用中，回忆和龋齿预防能力最重要。具体目的：1。通过调节当前水泥的粘度，在维持高Ca和Po4离子释放，回想矿化的潜力和更大的强度的同时，在体外和原位制剂中开发和测试原位制剂，而不是玻璃离子化合物； 2。产生回想起龋齿修复材料； 3。开发一种缓释可生物降解的涂层，用于过度敏感的牙齿，龋齿修复和预防； 4。在临床试验中，制定了回想起正畸和牙冠和桥梁的水泥，并研究牙釉质保护免受正畸水泥的保护。这项研究的完成将导致Ca-po4水泥和复合材料，并改善对牙本质的粘附，并改善了艺术和龋齿的治疗。