HIV PREVENTION FOR STD CLINIC PATIENTS

性病诊所患者的艾滋病毒预防

• 批准号: 6873037
• 负责人: MICHAEL P CAREY
• 金额: $ 65.54万
• 依托单位: SYRACUSE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6873037
• 关键词: AIDS education /prevention; HIV infections; behavior therapy; behavioral /social science research tag; clinical research; health behavior; human subject; patient oriented research; sex behavior; sexually transmitted diseases

DESCRIPTION (provided by applicant): The long-term objective of this research is to develop a feasible and effective HIV prevention strategy for use in publicly funded sexually transmitted disease (STD) clinics. Even though patients attending STD clinics are infected with HIV at alarmingly high rates, many do not know their HIV serostatus, decline HIV testing, and show limited interest in attending more intensive prevention programs. The proposed research will evaluate whether a two-step approach to HIV prevention, which is guided by behavioral science theory and features both motivational and skills components, achieves three important outcomes: (a) improved participation in HIV prevention services, (b) reduced risky sexual practices, and (c) decreased incidence of STDs. Women (n = 777) and men (n = 777) seeking care at a large, publicly-funded STD clinic will be recruited and provide informed written consent. Participants will complete a computer-administered survey at an initial clinic visit, and then will be randomly assigned to one of six intervention conditions. The six interventions will be formed by crossing a brief clinic-based component (two arms: brief motivational vs. brief informational) with a subsequent intensive component (three arms: skills-based vs. information-based vs. no treatment control). After completing both steps of the intervention, patients will be re-assessed at three, 6, and 12-month follow-ups using data obtained from observed participation in HIV prevention services, self-reported behavior, biological specimens, and medical records. Key dependent measures include short-term behavioral outcomes (agreeing to HIV testing, returning for HIV test results, and attending an intensive prevention program) and longer-term behavioral and biological outcomes (sexual risk behavior and incidence of STDs). The investigators predict that the brief motivational component will increase participation in HIV prevention services, and that the intensive skills-based component will reduce risk behavior and lead to fewer incident infections. It is also expected that patients receiving the motivational component will benefit most from the intensive component. The proposed research addresses a critical national and international HIV prevention priority, namely, motivating high-risk patients to engage in, and benefit from, HIV prevention services. The innovative use of a two-step approach, coupling motivational and behavioral skills components, will advance HIV prevention science and practice.

描述（由申请人提供）：这项研究的长期目标是制定可行有效的预防艾滋病毒预防策略，以用于公共资助的性传播疾病（STD）诊所。 即使参加性病诊所的患者以令人震惊的高率感染了HIV，但许多人不知道他们的艾滋病毒血清，衰落的艾滋病毒测试，并显示出对参加更密集的预防计划的兴趣有限。 拟议的研究将评估一种由行为科学理论指导并具有动机和技能组成部分指导的两步预防艾滋病毒预防方法，取得了三个重要的结果：（a）改善了参与HIV预防服务的参与，（b）降低风险的性行为，以及（C）STDS的降低。将招募妇女（n = 777）和男性（n = 777）在大型公共资助的性病诊所寻求护理的妇女（n = 777），并提供知情的书面同意。 参与者将在初次诊所就诊时完成一项计算机管理调查，然后将其随机分配到六个干预条件之一。 这六项干预措施将通过跨越简短的基于诊所的组件（两个武器：简短的动机与简短信息性）以及随后的密集组件（三个ARM：基于技能的基于信息与基于信息的治疗控制）形成。 完成两步的干预步骤后，使用观察到的参与HIV预防服务，自我报告的行为，生物学标本和医疗记录获得的数据将在三、6和12个月的随访中重新评估患者。 关键的依赖措施包括短期行为结果（同意艾滋病毒测试，返回艾滋病毒测试结果以及参加密集的预防计划）和长期的行为和生物学结果（性行为的性风险行为和性病的发生率）。 调查人员预测，简短的动机组成部分将增加参与HIV预防服务，而基于技能的密集组件将减少风险行为并导致较少的事件感染。 还可以预期，接受动机成分的患者将从密集的组成部分中受益最大。 拟议的研究涉及至关重要的国家和国际艾滋病毒预防优先级，即激励高危患者参与艾滋病毒预防服务并从中受益。 两步方法的创新使用，耦合动机和行为技能组成部分将推动艾滋病毒预防科学和实践。