Mast Cell Nerve Interactions in Airways

气道中肥大细胞神经相互作用

• 批准号: 6826247
• 负责人: Bradley Joel Undem
• 金额: $ 28.61万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-03-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6826247
• 关键词: Mast; Cell; Nerve; Interactions; Airways

EXCEED THE SPACE PROVIDED. Both the irritating as well asthe potentially debilitating _ymptoms of allergic airway disease are due in large parl to perturbation is neur6t_al activity. Thus sneezing, nonproductive coughing, increases mucus secretion, reversible bronchospasm, and inordinate sensations of dyspnea are a Consequence of abnormal afferent (sensory) input to the central nervous system, alterations in signal processing within the CNS, and/or alterations in the function of parasympathetic nerves. There has been much knowledge gained in the past two decades regarding the immunological and biochemical basis of the inflammation that accompanies allergic airway disease. Relatively little remains known, however, about how this inflammation modulates airway sensory and autonomic innervation such that the symptoms of disease occur. The long-range goal of this proposal is to develop at a better understanding of the mechanism and mediators involved in allergen-induced neuromodulation of the airways. The effect of allerlgen challenge on sensory afferent nerves and autonomic parasympathetic nerves innervating the airways will be investigated. Standard electrophysiologicat and immunohistochernical methods on airways isolated from guinea pigs and human tissue donors to directly address the mechanisms by which antigen challenge modulates neuronal function at a singel cell level in the airways. The results from this multidisciplinary approach should be of intrinsic value inproviding new knowledge regarding the cellular neurophysiology of the airways. The results may also shed new light on the complex pathophysiology of allergic airway diseases such as asthma, and ultimately suggest new therapeutic strategies for treatment of these complex diseases. PERFORMANCE SITE ========================================Section End===========================================

超出所提供的空间。过敏性气道疾病的刺激性症状和潜在的使人衰弱的症状在很大程度上是由于神经活动的扰动造成的。因此，打喷嚏、干咳、粘液分泌增加、可逆性支气管痉挛和呼吸困难的异常感觉是中枢神经系统异常传入（感觉）输入、中枢神经系统内信号处理改变和/或中枢神经系统功能改变的结果。副交感神经。在过去的二十年里，人们对过敏性气道疾病伴随的炎症的免疫学和生化基础有了很多了解。然而，关于这种炎症如何调节气道感觉和自主神经支配从而导致疾病症状的发生，人们知之甚少。该提案的长期目标是更好地理解过敏原诱导的气道神经调节的机制和介质。将研究过敏原激发对支配气道的感觉传入神经和自主副交感神经的影响。对豚鼠和人体组织供体分离的气道进行标准电生理学和免疫组织化学方法，以直接解决抗原激发在气道单细胞水平上调节神经元功能的机制。这种多学科方法的结果应该具有内在价值，可以提供有关气道细胞神经生理学的新知识。研究结果还可能为哮喘等过敏性气道疾病的复杂病理生理学提供新的线索，并最终为治疗这些复杂疾病提出新的治疗策略。表演网站==========================================部分结束====== =======================================