Multi-Center Osteoarthritis Study

多中心骨关节炎研究

• 批准号: 6925384
• 负责人: MICHAEL C NEVITT
• 金额: $ 93.86万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6925384
• 关键词: 25 hydroxycholecalciferol; X ray; biomechanics; blood chemistry; body physical activity; bone density; cooperative study; disease /disorder prevention /control; disease /disorder proneness /risk; gender difference; human genetic material tag; human middle age (35-64); human subject; interview; knee; longitudinal human study; magnetic resonance imaging; muscle strength; musculoskeletal disorder diagnosis; musculoskeletal injury; obesity; orthopedics; osteoarthritis; pathologic process; patient oriented research; questionnaires; tissue resource /registry; urine; vitamin C deficiency; vitamin D deficiency; vitamin E deficiency

DESCRIPTION (provided by applicant): Osteoarthritis (OA) is the most common form of arthritis, and disease in the knee or hip are leading causes of disability. Most epidemiologic studies of knee and hip OA have focused on radiographic disease, but symptomatic OA should be a major focus of studies on preventing OA, because symptomatic disease causes disability and has formidable societal and public health impacts. OA is potentially preventable, but only a limited number of mostly nonmodifiable risk factors has been identified, even though modifiable risk factors such as particular activities, muscle weakness, proprioceptive deficits, micronutrient deficiencies and structural factors have been proposed and may affect substantially the risk of disease. Prevention opportunities are most relevant and are most likely to be used by those who already have disease or who are at highest risk of getting it. This proposal introduces four new approaches into the epidemiologic study of knee osteoarthritis: l.a focus on symptomatic disease, 2. a comprehensive evaluation of risk factors including modifiable ones, 3. a focus on those who would really benefit from prevention opportunities, those who already have disease or those who are at high risk of getting it and 4. the incorporation of more comprehensive and reproducible imaging than has previously been used including, state of the art radiographic techniques and MRI. MRI provides rich information on structural factors in which abnormalities may affect the risk of disease. The overall objective of this study is to evaluate longitudinally the effects of three groups of factors: biomechanical factors (squatting, kneeling, stair climbing, wearing high heeled shoes, quadriceps weakness and proprioceptive deficits), bone and structural factors (bone density, bone marrow and meniscal lesions on MRI) and micronutrient deficiencies (vitamin C, E and D) on the occurrence and progression of symptomatic and radiographic knee OA in a population-based sample of men and women aged 50 to 79. Although the focus of this project is knee OA, we also incorporate a study of hip OA. We propose to recruit a community-based sample of 3,000 men and women likely to either have knee OA or be at high risk of OA. High risk groups will include those who are overweight, those with knee symptoms and those with a history of knee injuries or operations. Subjects will be evaluated with symptom questionnaires, radiographs and MRI?s and will be followed 36 months for the development or progression of symptomatic or radiographic OA. Analyses will focus on the relation of these important risk factors and OA outcomes. This large, multifaceted study offers to address definitively the relation of potentially important risk factors to the development or progression of a major disabling disease and to provide new insights into disease biology and potential opportunities for disease prevention.

描述（由申请人提供）：骨关节炎（OA）是最常见的 关节炎的形式和膝盖或臀部的疾病是主要原因 残疾。大多数膝盖和臀部OA的流行病学研究都集中在 影像学疾病，但有症状的OA应该是研究的重点 防止OA，因为有症状性疾病会导致残疾，并且具有强大的 社会和公共卫生影响。 OA可能是可以预防的，但只有一个 已经确定了有限数量的大多数不可修改的危险因素，即使 尽管可改变的风险因素，例如特定活动，肌肉无力，但 本体感受缺陷，微量营养素缺陷和结构因素具有 已提出，可能会影响疾病的风险。预防 机会最相关，最有可能被那些 已经患有疾病或有最高风险。 该提案将四种新方法引入了有关的流行病学研究 膝盖骨关节炎：L.A专注于症状疾病，2。 评估包括可修改的风险因素，3。 真的会从预防机会中受益，那些已经拥有的人 疾病或有高风险的人和4。 比以前使用的更全面和可重复的成像 包括最先进的射线照相技术和MRI。 MRI提供富裕 有关异常可能影响风险的结构因素的信息 疾病。 这项研究的总体目的是纵向评估影响 三组因素：生物力学因素（蹲，跪，楼梯 攀登，穿高跟鞋，股四头肌的弱点和本体感受 缺陷），骨骼和结构因子（骨密度，骨髓和半月板 MRI）和微量营养素缺乏症（维生素C，E和D）的病变 症状和射线照相膝关节OA的发生和进展 基于人群的男性和50至79岁的男女样本。尽管 该项目是膝盖OA，我们还纳入了髋关节OA的研究。 我们建议招募一个基于社区的样本，包括3,000名男性和女性 膝盖OA要么有OA的高风险。高风险组将包括 那些超重，患有膝盖症状的人以及有历史的人 膝盖受伤或手术。受试者将通过症状评估 问卷，X光片和MRI，将在36个月内进行36个月 有症状或射线照相OA的发展或进展。分析将 专注于这些重要的风险因素和OA结果的关系。 这项大型多方面的研究提供了最终解决的关系 潜在的重要风险因素，导致主要的发展或发展 禁用疾病，并提供有关疾病生物学和的新见解 预防疾病的潜在机会。