Measurement & Prediction of Everyday Function Dementia

测量

• 批准号: 6943498
• 负责人: SARAH E TOMASZEWSKI-FARIAS
• 金额: $ 12.74万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6943498
• 关键词: aging; behavioral /social science research tag; brain morphology; clinical research; cognition disorders; data collection methodology /evaluation; dementia; diagnosis design /evaluation; functional ability; functional magnetic resonance imaging; human old age (65+); human subject; longitudinal human study; memory; mental disorder diagnosis; neuroanatomy; neuroimaging; neuropsychological tests; neuropsychology; prognosis; statistics /biometry

DESCRIPTION (provided by applicant): This five-year career development plan is designed to further refine the candidate's research skills, enabling her to become an independent and productive researcher focused on the assessment of everyday functional impairments in older adults. The training plan emphasizes three content areas: 1) test development of ecologically valid measures for use with older adults; 2) the integration of structural imaging techniques into neuropsychological research; and 3) research design and statistical analysis. Learning objectives will be met utilizing several training modalities: a) regularly scheduled structured meetings with Sponsors, Mentors, and Consultants; b) formal coursework; c) attendance at regular on-site research colloquia and annual scientific conferences; and d) direct research experience. The aim of this project is to develop a method of conceptualizing and measuring everyday function that is: 1) grounded in neuroanatomy and neuropsychology, 2) sensitive to a wide spectrum of functional change and; 3) useful in understanding how a multitude of factors can contribute to, and/or mediate everyday function. Study participants will include individuals diagnosed with mild cognitive impairment or dementia, and a sample of cognitively normal older adults. The proposed model of the functional changes associated with dementia has been adapted from the classification system set forth by the World Health Organization (WHO), [96] which describe the consequence of disease at three levels: impairment, disability, and handicap. These levels can be hierarchically arranged wherein 'impairments' (observable, externalized neurological manifestations of disease) are precursors to 'disability' (declines in the ability to carry out activities essential to normal life), which in turn is a precursor to 'handicap' (the social consequence of disease). In this project, all three levels of functional change will be assessed, with a particularly emphasis on assessing functional change at the level of impairment in order to increase the sensitivity to early functional changes associated with the preclinical and early stages of dementia. A new scale will be developed to assess functional impairments, which organizes these impairments into neuropsychologically and neuroanatomically-relevant domains. Measures of disability and preliminary assessment of handicap will also be included to examine the relationship between the different levels functional change set forth in the model.

描述（由申请人提供）：这项为期五年的职业发展计划旨在进一步完善候选人的研究技能，使她成为一名专注于评估老年人日常功能障碍的独立和富有成效的研究人员。培训计划强调了三个内容：1）测试与老年人使用的生态有效措施的开发； 2）将结构成像技术的整合到神经心理学研究中； 3）研究设计和统计分析。学习目标将通过几种培训方式实现：a）与赞助商，导师和顾问定期安排的结构性会议； b）正式课程； c）参加常规现场研究口交和年度科学会议； d）直接研究经验。该项目的目的是开发一种概念化和测量日常功能的方法：1）基于神经解剖学和神经心理学的基础，2）对各种功能变化敏感敏感； 3）有助于了解多种因素如何促进和/或中介日常功能。 研究参与者将包括被诊断出患有轻度认知障碍或痴呆症的人，以及认知正常的老年人样本。与痴呆症相关的功能变化的拟议模型已改编自世界卫生组织（WHO），[96]所提出的分类系统，这些系统描述了三个层次的疾病后果：障碍，残疾和障碍。这些水平可以在层次上排列，其中“损害”（可观察的，外部化的神经系统疾病表现）是“残疾”的前体（在进行正常生命必不可少的活动能力的下降），这反过来又是“障碍”的先驱（疾病的社会后果）。在该项目中，将评估所有三个级别的功能变化级别，并特别着重于评估损害水平上的功能变化，以提高对与痴呆症的临床前和早期阶段相关的早期功能变化的敏感性。将开发一个新的量表来评估功能障碍，该功能障碍将这些障碍组织到神经心理学和神经解剖学上的领域。还将包括对残障的残疾和初步评估的度量，以检查模型中规定的不同级别功能变化之间的关系。