Oxidative Stress, Aging and Alzheimer's Disease

氧化应激、衰老和阿尔茨海默病

• 批准号: 6868496
• 负责人: Zoe Arvanitakis
• 金额: $ 15.56万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-15 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6868496
• 关键词: Alzheimer' s disease; Parkinson' s disease; aging; antioxidants; biomarker; clinical research; cognition; deoxyguanosine; disease /disorder proneness /risk; epidemiology; human mortality; human subject; human tissue; longitudinal human study; neural degeneration; oxidative stress; patient oriented research; psychomotor function; sign /symptom

The overall goal of this Mentored Patient-Oriented Research Career Award is to provide the applicant Development with the necessary tools to become an independent investigator in aging and Alzheimer's disease, through the conduct of an epidemiologic study of risk factors for incident Alzheimer's disease, change in cognitive and motor function, and risk of death. Prior work suggesting that Alzheimer's disease and parkinsonian signs are strongly related, raises the possibility of shared etiopathogenesis. We propose to examine oxidative stress as a risk factor for incident Alzheimer's disease, change in cognitive function and progression of parkinsonian signs, and risk of death. The proposed study will take advantage of frozen serum specimens from 900 persons without dementia participating in the Religious Orders Study, an ongoing epidemiologic study of aging and Alzheimer's disease, and longitudinal clinical data from annual structured clinical evaluations. There are already approximately 150 cases of incident disease and 200 deaths. In addition to this focused, structured, and timely research project, the career development plans include structured mentoring in a highly successful, multidisciplinary environment, and a program of formal course work that will lead to a Masters of Science in Clinical Research.

这项受过指导的以患者为导向的研究职业奖的总体目标是为申请人开发提供必要的工具，以成为衰老和阿尔茨海默氏病的独立研究者，通过对发生阿尔茨海默氏病的危险因素的流行病学研究，认知和运动的变化以及死亡的风险。先前的工作表明，阿尔茨海默氏病和帕金森氏症的迹象密切相关，这增加了共同的疗法发生的可能性。我们建议将氧化应激视为发生阿尔茨海默氏病的危险因素，认知功能的变化和帕金森氏症征兆的进展以及死亡的风险。拟议的研究将利用参与宗教秩序研究的900人的冷冻血清标本，一项持续的衰老和阿尔茨海默氏病的流行病学研究以及年度结构性临床评估的纵向临床数据。已经大约有150例事件疾病和200例死亡。除了这个重点，结构化和及时的研究项目外，职业发展计划还包括在非常成功的多学科环境中进行结构化指导，以及将导致临床研究科学硕士学位的正式课程工作计划。