DISCHARGE PATTERNS OF MOTONEURONS

运动神经元的放电模式

基本信息

批准号：
6830771
负责人：
PEDRO N RUDOMIN
金额：
$ 15.35万
依托单位：
CINVESTAV-IPN
依托单位国家：
美国
项目类别：
财政年份：
1990
资助国家：
美国
起止时间：
1990-12-01 至 2006-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6830771
关键词：
cats central neural pathway /tract cutaneous sensory nerve dorsal horn electrophysiology inflammation membrane potentials motor neurons nerve injury neural conduction neural inhibition neuromuscular function neuroregulation sensorimotor system sensory mechanism somatic afferent nerve synapses

项目摘要

DESCRIPTION (provided by applicant): The general objective of our research has been to understand the mechanisms and functional organization of the spinal pathways involved in the presynaptic control of the synaptic effectiveness of muscle, cutaneous and joint afferents and the role of these mechanisms in motor performance and sensory discrimination. One, perhaps the most attractive issue that has emerged from the studies we have performed during the last few years, is the finding of central mechanisms that produce a differential inhibition of the primary afferent depolarization (PAD) elicited in the intraspinal collaterals of individual muscle spindle afferents. This allows, at least in principle, a selective addressing of the information generated in the periphery to specific sets of neurons. One of the Specific Aims of this proposal is to analyze the extent to which the differential control of PAD observed in muscle and cutaneous afferents has any functional consequences on the postsynaptic responses elicited by these inputs in different sets of target neurons. Another, relatively unexplored aspect of the presynaptic control mechanisms, is its plasticity and adaptability in response to inflammation and peripheral nerve damage or conduction block. We now propose to study, in the anesthetized cat, the alterations in the presynaptic control of synaptic actions of joint afferents during acute inflammation of joints and skin, in view of pronounced changes in reflex actions caused by inflammatory processes, as well as the changes in the presynaptic control of transmission from cutaneous afferents following the unmasking of spinal reflexes caused by peripheral nerve damage or conduction block. We have shown recently that in the anesthetized cat there is a set spontaneously active dorsal horn neurons that modulates impulse transmission in several spinal pathways, including those mediating presynaptic inhibition of muscle and cutaneous afferents. We will now explore the functional organization of this set of neurons and some of the pathways and mechanisms that may be involved in the synchronization of their activity, and how this activity is modified by peripheral nerve damage and acute inflammation of the skin.

描述（由申请人提供）：我们研究的一般目标曾了解脊柱的机制和功能组织参与突触前控制的途径的突触有效性肌肉，皮肤和关节传感以及这些机制在电机中的作用性能和感觉歧视。一个，也许是最吸引人的问题这是我们过去几年所做的研究中得出的，是发现中心机制会产生差异抑制主要传入去极化（PAD）单个肌肉主轴传入的侧支。至少在原理，对周围生成的信息的选择性解决特定的神经元集。该提议的具体目的之一是分析在肌肉中观察到的垫子的差分控制的程度皮肤传入对突触后有任何功能后果这些输入在不同的目标神经元集中引起的响应。突触前控制机制的另一个相对尚未探索的方面是它响应炎症和周围的可塑性和适应性神经损伤或传导阻滞。我们现在建议在麻醉中学习猫，关节突触作用突触前的改变关节和皮肤急性炎症期间的传入，鉴于明显由炎症过程引起的反射动作的变化以及皮肤传感器传播的突触前控制的变化遵循由周围神经损伤引起的脊柱反射或传导块。我们最近表明，在麻醉的猫中有一个自发活跃的背角神经元调节冲动在几种脊柱途径中的传播，包括介导的突触前的途径抑制肌肉和皮肤传入。我们现在将探索这组神经元和一些途径的功能组织可能参与其活性同步的机制，以及该活动如何通过周围神经损伤和急性炎症来改变皮肤。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Markovian Analysis of the Sequential Behavior of the Spontaneous Spinal Cord Dorsum Potentials Induced by Acute Nociceptive Stimulation in the Anesthetized Cat.

麻醉猫急性伤害性刺激诱发的自发脊髓背电位序列行为的马尔可夫分析。

DOI：
10.3389/fncom.2017.00032
发表时间：
2017
期刊：
Frontiers in computational neuroscience
影响因子：
3.2
作者：
Martin,Mario;Béjar,Javier;Esposito,Gennaro;Chávez,Diógenes;Contreras-Hernández,Enrique;Glusman,Silvio;Cortés,Ulises;Rudomín,Pablo
通讯作者：
Rudomín,Pablo

Multichannel detrended fluctuation analysis reveals synchronized patterns of spontaneous spinal activity in anesthetized cats.

DOI：
10.1371/journal.pone.0026449
发表时间：
2011
期刊：
PloS one
影响因子：
3.7
作者：
Rodríguez EE;Hernández-Lemus E;Itzá-Ortiz BA;Jiménez I;Rudomín P
通讯作者：
Rudomín P

A machine learning methodology for the selection and classification of spontaneous spinal cord dorsum potentials allows disclosure of structured (non-random) changes in neuronal connectivity induced by nociceptive stimulation.

DOI：
10.3389/fninf.2015.00021
发表时间：
2015
期刊：
Frontiers in neuroinformatics
影响因子：
3.5
作者：
Martin M;Contreras-Hernández E;Béjar J;Esposito G;Chávez D;Glusman S;Cortés U;Rudomin P
通讯作者：
Rudomin P

Interaction of baseline synaptic noise and Ia EPSPs: evidence for appreciable negative correlation under physiological conditions.

基线突触噪声和 Ia EPSP 的相互作用：生理条件下明显负相关的证据。