METAL MIXTURES AND CHILDREN'S HEALTH

金属混合物与儿童健康

• 批准号: 6750921
• 负责人: Howard Hu
• 金额: $ 73.95万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6750921
• 关键词: clinical research; environmental exposure; environmental health; human subject; metal poisoning; minings

We propose to establish a Center for Children's Environmental Health and Disease Prevention Research that addresses the concerns of a community living in the Tar Creek Superfund site of Oklahoma - an area highly contaminated by metals (lead, cadmium, iron, manganese, and others) in mining waste and populated by many residents of Native American descent. Our overall goal is to take a highly innovative and integrated approach to addressing a "real world" problem, i.e., the potential of the mixtures of metals that are present in "chat" (mining waste) to interact with each other in terms of exposure, absorption, dose, and adverse effects on the development of children. Our Center will pursue four Research Projects with the support of four Cores. Project 1 will be a community-based participatory epidemiologic study that examines biological markers of fetal and early childhood exposure to metals (lead, manganese, cadmium, and iron), their impact on measures of mental development, and their response to a quasi-experimental randomized trial of nutritional and behavioral interventions. Project 2 will assess the utility of size fractionation and sequential extraction studies for characterizing chat, conduct a nested case-control study of the determinants of high versus low burdens of metals amongst children participating in Project 1, and produce standardized "homogenized chat" for Projects 3 and 4. Project 3 will investigate the expression of binding and transporter molecules for metal transport and the corresponding pharmacokinetics of metals from the lung and gut to the blood, CNS and other organs as they relate to pregnant rats and their weanlings. Project 4 will examine the effect of pre- and neo-natal exposure to metals on neurochemical changes and neurobehavioral outcomes in rats. The effect of simple mixtures of metals will be compared with the effect of "homogenized chat" in both Projects 3 and 4. The potential effect of stress from living near toxic waste will be explored in Project 1 and the potential modifying effect of stress on metals neurotoxicity will also be explored in Project 4. Our Administrative, Analytical Chemistry, and Biostatistics Cores will enable us to fully integrate and support our research, and our Community Outreach and Translation Core will utilize an innovative portfolio of outreach activities developed in conjunction with a broadly-based Community Advisory Board to develop awareness and influence behaviors and health practices in order to prevent adverse health effects in children from exposure to metals in mining waste.

我们提议建立一个儿童环境健康和疾病预防研究中心，以解决居住在俄克拉荷马州焦油溪超级基金所在地的社区所关心的问题，该地区是一个受到金属（铅、镉、铁、锰等）高度污染的地区。采矿废料，居住着许多美洲原住民后裔。我们的总体目标是采取高度创新和综合的方法来解决“现实世界”的问题，即“聊天”（采矿废物）中存在的金属混合物在暴露方面相互作用的潜力、吸收、剂量以及对儿童发育的不良影响。 我们中心将在四个核心的支持下开展四个研究项目。项目 1 将是一项以社区为基础的参与性流行病学研究，检查胎儿和幼儿接触金属（铅、锰、镉和铁）的生物标志物、它们对智力发育指标的影响以及它们对准实验的反应。随机试验 的营养和行为干预。项目 2 将评估大小分级和顺序提取研究在描述聊天特征方面的效用，对参与项目 1 的儿童中金属含量高与低的决定因素进行巢式病例对照研究，并为项目生成标准化的“均质聊天” 3和4。项目3将研究金属转运的结合和转运分子的表达，以及金属从肺和肠道到血液、中枢神经系统和其他器官的相应药代动力学，因为它们与怀孕大鼠及其后代有关。断奶仔猪。项目 4 将检查 产前和新生儿接触金属对大鼠神经化学变化和神经行为结果的影响。金属简单混合物的效果将与项目 3 和 4 中的“均质聊天”效果进行比较。项目 1 将探讨生活在有毒废物附近的压力的潜在影响以及压力对金属的潜在改变效果 项目 4 还将探讨神经毒性。我们的行政、分析化学和生物统计学核心将使我们能够充分整合和支持我们的研究，我们的社区外展和翻译核心将利用与广泛的合作开发的创新外展活动组合。以社区咨询委员会为基础，提高认识和 影响行为和健康习惯，以防止儿童因接触采矿废料中的金属而对健康产生不利影响。