Blood Pressure in Postmenopausal Women: A GCRC Study

绝经后妇女的血压：GCRC 研究

• 批准号: 6889612
• 负责人: Ellen W Seely
• 金额: $ 14.95万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-15 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6889612
• 关键词: angiotensin /renin /aldosterone hypertension; biopsy; blood pressure; clinical research; estradiol; estrogen receptors; gene expression; genetic polymorphism; genotype; hormone regulation /control mechanism; human subject; northern blottings; patient oriented research; polymerase chain reaction; postmenopause; potentiometry; radioimmunoassay; renin angiotensin system; statistics /biometry; women' s health

DESCRIPTION (provided by applicant): This is a Mid-Career Investigator (K 24) proposal for Ellen Seely, MD. The goal of this proposal is threefold. First, it would increase the depth of Dr. Seely's research by enabling the investigator to receive further advanced training in human genetics. Second, it would give the investigator the supported time to formally train young investigators in patient-oriented research in the field of hormonal control of blood pressure. Third, it would allow the investigator to use her experience as Associate Program Director of the General Clinical Research Center (GCRC) to teach the next generation of patient-oriented researchers about the use of a GCRC for the study of human pathophysiology using varied GCRC-based investigative techniques. Dr. Seely's research topic "Blood Pressure in Postmenopausal Women: a GCRC Study" serves as fertile ground for a K24. Hypertension affects over 20 million women in the United States and the majority of these women are postmenopausal. Although there is clearly a genetic component to hypertension in both men and women, its incidence increases dramatically in women following menopause superceding that in men and suggests that the hormonal milieu of the premenopausal state may be protective against the manifestation of hypertension. The overall goal of Dr. Seely's research plan is to utilize the GCRC for detailed studies of the pathophysiology of hypertension in postmenopausal women. Dr. Seely plans to determine how polymorphisms of genes of the renin-angiotensin-aldosterone system (RAAS), a major regulator of blood pressure, are influenced by estradiol. An understanding of the interaction of estradiol with specific polymorphisms of the RAAS that lead to blood pressure lowering may enable the development of selective estrogen receptor modulators that have antihypertensive effects. Thus, funding of this proposal will allow Dr. Seely to expand her own research career and simultaneously provide time to expand her mentorship role.

描述（由申请人提供）：这是医学博士 Ellen Seely 的职业生涯中期调查员 (K 24) 提案。 该提案有三个目标。 首先，它将使西利博士能够接受人类遗传学方面的进一步高级培训，从而增加西利博士研究的深度。 其次，这将为研究者提供时间来正式培训年轻研究者，以进行血压激素控制领域以患者为导向的研究。 第三，这将使研究者能够利用她作为普通临床研究中心 (GCRC) 项目副主任的经验，向下一代以患者为导向的研究人员传授如何使用 GCRC 使用不同的 GCRC 来研究人类病理生理学。基于调查技术。 Seely 博士的研究课题“绝经后妇女的血压：GCRC 研究”为 K24 提供了沃土。 高血压影响着美国超过 2000 万女性，其中大多数女性已绝经。 尽管男性和女性的高血压显然都存在遗传因素，但绝经后女性的发病率急剧增加，超过了男性，这表明绝经前状态的荷尔蒙环境可能可以预防高血压的表现。 Seely 博士研究计划的总体目标是利用 GCRC 对绝经后妇女高血压的病理生理学进行详细研究。 Seely 博士计划确定雌二醇如何影响肾素-血管紧张素-醛固酮系统 (RAAS)（血压的主要调节因子）的基因多态性。 了解雌二醇与导致血压降低的 RAAS 特定多态性的相互作用可能有助于开发具有抗高血压作用的选择性雌激素受体调节剂。 因此，该提案的资助将使 Seely 博士能够扩大自己的研究生涯，同时提供时间来扩大她的指导作用。