Blood Pressure in Postmenopausal Women: A GCRC Study

绝经后妇女的血压：GCRC 研究

• 批准号: 6889612
• 负责人: Ellen W Seely
• 金额: $ 14.95万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-15 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6889612
• 关键词: angiotensin /renin /aldosterone hypertension; biopsy; blood pressure; clinical research; estradiol; estrogen receptors; gene expression; genetic polymorphism; genotype; hormone regulation /control mechanism; human subject; northern blottings; patient oriented research; polymerase chain reaction; postmenopause; potentiometry; radioimmunoassay; renin angiotensin system; statistics /biometry; women' s health

DESCRIPTION (provided by applicant): This is a Mid-Career Investigator (K 24) proposal for Ellen Seely, MD. The goal of this proposal is threefold. First, it would increase the depth of Dr. Seely's research by enabling the investigator to receive further advanced training in human genetics. Second, it would give the investigator the supported time to formally train young investigators in patient-oriented research in the field of hormonal control of blood pressure. Third, it would allow the investigator to use her experience as Associate Program Director of the General Clinical Research Center (GCRC) to teach the next generation of patient-oriented researchers about the use of a GCRC for the study of human pathophysiology using varied GCRC-based investigative techniques. Dr. Seely's research topic "Blood Pressure in Postmenopausal Women: a GCRC Study" serves as fertile ground for a K24. Hypertension affects over 20 million women in the United States and the majority of these women are postmenopausal. Although there is clearly a genetic component to hypertension in both men and women, its incidence increases dramatically in women following menopause superceding that in men and suggests that the hormonal milieu of the premenopausal state may be protective against the manifestation of hypertension. The overall goal of Dr. Seely's research plan is to utilize the GCRC for detailed studies of the pathophysiology of hypertension in postmenopausal women. Dr. Seely plans to determine how polymorphisms of genes of the renin-angiotensin-aldosterone system (RAAS), a major regulator of blood pressure, are influenced by estradiol. An understanding of the interaction of estradiol with specific polymorphisms of the RAAS that lead to blood pressure lowering may enable the development of selective estrogen receptor modulators that have antihypertensive effects. Thus, funding of this proposal will allow Dr. Seely to expand her own research career and simultaneously provide time to expand her mentorship role.

描述（由申请人提供）：这是医学博士Ellen Seely的中期研究员（K 24）提案。 该提议的目标是三倍。 首先，它将通过使研究人员获得进一步的人类遗传学培训来增加Seely博士的研究深度。 其次，它将为研究人员提供支持的时间，以正式培训年轻的研究者在血压荷尔蒙控制领域的以患者为导向的研究。 第三，这将使研究人员能够利用她担任一般临床研究中心（GCRC）副计划主任的经验，可以教给下一代患者的研究人员使用GCRC使用基于GCRC的不同研究技术来研究人类病理生理学的研究。 Seely博士的研究主题“绝经后妇女的血压：GCRC研究”是K24的肥沃基础。 在美国，高血压会影响超过2000万妇女，而这些妇女中的大多数是绝经后。 尽管显然有男性和女性高血压的遗传成分，但在更年期后，女性的发病率急剧增加，在男性中，在男性中表明，绝经前状态的荷尔蒙环境可能可以保护反对高血压的表现。 Seely博士研究计划的总体目标是利用GCRC进行绝经后妇女高血压病理生理学的详细研究。 Seely博士计划确定肾素 - 血管紧张素 - 醛固酮系统（RAAS）的多态性如何受到血压的主要调节剂，受雌二醇的影响。 对雌二醇与RAA的特定多态性的相互作用的理解可能导致血压降低，这可能使选择性雌激素受体调节剂的发展具有降压作用。 因此，该提案的资金将使Seely博士能够扩大自己的研究生涯，并同时提供时间来扩大她的指导职务。