Laser-Engineered Net Shape Ti/HA Composite Implants

激光设计的净形状 Ti/HA 复合植入物

• 批准号: 6443481
• 负责人: Harold Alexander
• 金额: $ 10万
• 依托单位: BIOLOK INTERNATIONAL, INC.-ORTHOGEN CORP
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6443481
• 关键词: bioengineering /biomedical engineering; biomaterial compatibility; biomaterial development /preparation; bone regeneration; dogs; endosseous dental implant; hydroxyapatites; lasers; medical implant science; technology /technique development; titanium

DESCRIPTION: Endosseous Dental implants are in common use today throughout the world to treat single tooth loss and well as to support dentures. Tissue response to a Dental implant correlates with the composition, surface chemistry, and surface microgeometry of the implant material. The bioactivity of titanium alloy is to be improved through the addition of hydroxyapatite (HA) powder utilizing Laser Engineered Net Shaping (LENS) technology. CP titanium and 6Al-4V-Ti alloy have good biocompatibility but low bioactivity resulting in variable bone response to the implant surface. It is believed that a calcium rich surface potentiates platelet activation and improves fibrin binding to the implant surface. Surface modification through laser microgrooving and chemistry modification through LENS should result is more rapid bone growth and apposition up to the implant surface. The LENS process offers the opportunity to manufacture a unique HA impregnated Ti alloy Dental implant with a cost and ease similar to current manufacturing modalities incorporating optimum surface microgeometry, mechanical design, base material composition and surface chemistry. Such an implant could be implanted and loaded at the time of tooth extraction providing the patient with a cost effective new tooth after just one or two sittings, instead of the usual 3 to 6 months.

描述：骨内种植牙如今在全世界范围内得到普遍使用 治疗单颗牙齿缺失并支撑假牙的世界。组织 对牙种植体的反应与成分、表面相关 植入材料的化学和表面微观几何形状。生物活性 通过添加羟基磷灰石（HA）来改善钛合金的性能 采用激光工程净成型 (LENS) 技术的粉末。 CP钛 6Al-4V-Ti合金具有良好的生物相容性，但生物活性较低，导致 骨对种植体表面的反应可变。据认为，钙 丰富的表面增强血小板活化并改善纤维蛋白与血小板的结合 种植体表面。通过激光微槽和化学进行表面改性 通过 LENS 进行的修改应该会导致骨骼生长更快， 附着到种植体表面。 LENS 流程提供了机会 制造独特的 HA 浸渍钛合金牙科植入物，成本低廉 类似于当前的制造方式，结合了最佳表面 微观几何、机械设计、基材成分和表面 化学。这种种植体可以在牙齿生长时植入并加载 拔牙后即可为患者提供具有成本效益的新牙 或两次会议，而不是通常的 3 至 6 个月。