CENTRAL CONTROL OF OXYTOCIN RELEASE DURING GESTATION

妊娠期间催产素释放的集中控制

基本信息

  • 批准号:
    6865301
  • 负责人:
  • 金额:
    $ 29.08万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2000
  • 资助国家:
    美国
  • 起止时间:
    2000-03-01 至 2008-11-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The overall objective of this research project is to characterize the autoregulatory functions of central oxytocin (OT) on systemic OT release during reproductive states. OT is released during parturition to aid in uterine contraction, and OT secretion during nursing is essential for milk delivery and normal growth of the offspring. Recent studies find that the central OT system is activated during gestation, and participates in behavioral, anatomical, and physiological adaptations, which contribute to successful lactation. We have found that OT receptor (OTR) binding increases during gestation, and that blockade of OTR, only during gestation, decreases milk delivery to suckling offspring, resulting in reduced weight gain. However, the mechanism(s) by which OTR blockade during gestation diminishes lactational efficiency is unknown. We will test the HYPOTHESIS that OTR stimulation during gestation is required for genetic and electrophysiological adaptations necessary for 1) increased OT synthesis and 2) OT neuron sensitivity required for adequate milk delivery in response to suckling. To test this proposal, the SPECIFIC AIMS are to determine the effects of OTR blockade DURING GESTATION on; 1) OT binding in magnocellular nuclei, 2) OT mRNA in magnocellular nuclei and OT content in the neural lobe during gestation and mid-lactation, 3) development of OT neuron membrane and synaptic adaptations characteristic of lactation, and 4) response sensitivity of OT neurons to suckling and administration of excitatory neurotransmitters. These Aims will be addressed using receptor autoradiography, biochemical measures of OT mRNA, radioimmunoassay of OT in neural lobe, dialysate, and plasma, microdialysis, electrophysiological evaluation of isolated OT cells and in hypothalamic slices, and activation of c-fos in OT neurons. These measures will be performed on virgin animals, and pregnant animals following central administration of an OT antagonist or vehicle during mid-late gestation. Increasing efficiency of lactation to ensure adequate infant growth will increase the number of breast fed infants to recommended levels, which will decrease the incidence and severity of a wide range of illnesses and pathologies.
描述(由申请人提供):该研究项目的总体目的是表征中央催产素(OT)在生殖状态期间全身OT释放中的自动调节功能。 OT在分娩期间释放以帮助子宫收缩,而在护理过程中的OT分泌对于牛奶输送和后代正常生长至关重要。最近的研究发现,妊娠期间激活了中央OT系统,并参与行为,解剖和生理适应性,这有助于成功泌乳。我们发现,OT受体(OTR)结合在妊娠期间增加了增加,并且仅在妊娠期间,OTR的阻断会减少牛奶的递送至哺乳后代,从而减少体重增加。然而,妊娠期间OTR阻塞降低泌乳效率的机制尚不清楚。我们将测试以下假设:妊娠期间的OTR刺激是必需的遗传学和电生理适应性的1)1)增加了OT合成和2)2)对哺乳的适当牛奶递送所需的神经元敏感性。为了测试该建议,具体的目的是确定妊娠期间OTR阻断的影响; 1) OT binding in magnocellular nuclei, 2) OT mRNA in magnocellular nuclei and OT content in the neural lobe during gestation and mid-lactation, 3) development of OT neuron membrane and synaptic adaptations characteristic of lactation, and 4) response sensitivity of OT neurons to suckling and administration of excitatory neurotransmitters.这些目标将使用受体放射自显影,OT mRNA的生化测量,神经叶中OT的放射免疫分子,透析和血浆中的OT,微透析,微透析,分离的OT细胞的电生理评估,以及OT NEURONS中C-FOS的分离的OT细胞以及OT Neurors的活化。这些措施将对处女动物进行,并在中间妊娠期间进行中央拮抗剂或媒介物后进行怀孕的动物。提高泌乳效率以确保婴儿的足够生长将使婴儿的母亲数量增加到建议的水平,这将降低广泛的疾病和病理的发生率和严重程度。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

STEVEN BEALER BEALER其他文献

STEVEN BEALER BEALER的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('STEVEN BEALER BEALER', 18)}}的其他基金

Altered Baroreflex Responses by Dietary Sodium
膳食钠改变压力反射反应
  • 批准号:
    6652676
  • 财政年份:
    2000
  • 资助金额:
    $ 29.08万
  • 项目类别:
CENTRAL CONTROL OF OXYTOCIN RELEASE DURING GESTATION
妊娠期间催产素释放的集中控制
  • 批准号:
    6345831
  • 财政年份:
    2000
  • 资助金额:
    $ 29.08万
  • 项目类别:
CENTRAL CONTROL OF OXYTOCIN RELEASE DURING GESTATION
妊娠期间催产素释放的集中控制
  • 批准号:
    6024468
  • 财政年份:
    2000
  • 资助金额:
    $ 29.08万
  • 项目类别:
CENTRAL CONTROL OF OXYTOCIN RELEASE DURING GESTATION
妊娠期间催产素释放的集中控制
  • 批准号:
    6984838
  • 财政年份:
    2000
  • 资助金额:
    $ 29.08万
  • 项目类别:
Altered Baroreflex Responses by Dietary Sodium
膳食钠改变压力反射反应
  • 批准号:
    6352512
  • 财政年份:
    2000
  • 资助金额:
    $ 29.08万
  • 项目类别:
Altered Baroreflex Responses by Dietary Sodium
膳食钠改变压力反射反应
  • 批准号:
    6527886
  • 财政年份:
    2000
  • 资助金额:
    $ 29.08万
  • 项目类别:
CENTRAL CONTROL OF OXYTOCIN RELEASE DURING GESTATION
妊娠期间催产素释放的集中控制
  • 批准号:
    7336776
  • 财政年份:
    2000
  • 资助金额:
    $ 29.08万
  • 项目类别:
Altered Baroreflex Responses by Dietary Sodium
膳食钠改变压力反射反应
  • 批准号:
    6391012
  • 财政年份:
    2000
  • 资助金额:
    $ 29.08万
  • 项目类别:
CENTRAL CONTROL OF OXYTOCIN RELEASE DURING GESTATION
妊娠期间催产素释放的集中控制
  • 批准号:
    6363439
  • 财政年份:
    2000
  • 资助金额:
    $ 29.08万
  • 项目类别:
CENTRAL CONTROL OF OXYTOCIN RELEASE DURING GESTATION
妊娠期间催产素释放的集中控制
  • 批准号:
    6521249
  • 财政年份:
    2000
  • 资助金额:
    $ 29.08万
  • 项目类别:

相似国自然基金

适用于放射自显影的GAGG/SiPM探测器的空间分辨率物理极限研究
  • 批准号:
    62001466
  • 批准年份:
    2020
  • 资助金额:
    24 万元
  • 项目类别:
    青年科学基金项目
紫茎泽兰根际微生物群落结构、多样性和功能研究
  • 批准号:
    31360026
  • 批准年份:
    2013
  • 资助金额:
    50.0 万元
  • 项目类别:
    地区科学基金项目
用32P的放射自显影技术对经络循行路路线物质基础研究
  • 批准号:
    39570856
  • 批准年份:
    1995
  • 资助金额:
    6.0 万元
  • 项目类别:
    面上项目
大鼠全脑对针刺内关穴位的特异性反应
  • 批准号:
    39570855
  • 批准年份:
    1995
  • 资助金额:
    6.0 万元
  • 项目类别:
    面上项目
细菌周膜与内质网关系的电镜细胞化学和放射自显影研究
  • 批准号:
    39070436
  • 批准年份:
    1990
  • 资助金额:
    3.5 万元
  • 项目类别:
    面上项目

相似海外基金

CENTRAL CONTROL OF OXYTOCIN RELEASE DURING GESTATION
妊娠期间催产素释放的集中控制
  • 批准号:
    6984838
  • 财政年份:
    2000
  • 资助金额:
    $ 29.08万
  • 项目类别:
Regulation of Stromal Wound Healing by Growth Factors
生长因子对间质伤口愈合的调节
  • 批准号:
    7049490
  • 财政年份:
    1989
  • 资助金额:
    $ 29.08万
  • 项目类别:
Regulation of Stromal Wound Healing by Growth Factors
生长因子对间质伤口愈合的调节
  • 批准号:
    6874313
  • 财政年份:
    1989
  • 资助金额:
    $ 29.08万
  • 项目类别:
Regulation of Stromal Wound Healing by Growth Factors
生长因子对间质伤口愈合的调节
  • 批准号:
    6472340
  • 财政年份:
    1989
  • 资助金额:
    $ 29.08万
  • 项目类别:
Regulation of Stromal Wound Healing by Growth Factors
生长因子对间质伤口愈合的调节
  • 批准号:
    6806832
  • 财政年份:
    1989
  • 资助金额:
    $ 29.08万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了