Simultaneous Electrophysiology and functional MRI

同步电生理学和功能性 MRI

• 批准号: 6543338
• 负责人: Mark Steven Cohen
• 金额: $ 20.48万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6543338
• 关键词: attention; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; biomedical equipment safety; brain electrical activity; clinical research; computer program /software; computer system hardware; digital imaging; drug abuse; electrical potential; electrodes; electroencephalography; electrophysiology; emotions; evoked potentials; functional magnetic resonance imaging; human subject; method development; neuroimaging; sleep

Functional MRI (fMRI) has become a dominant tool in the physiological studies of human cognition and behavior. The moment- to-moment signaling within the brain, however, is understood to be fundamentally electrical. Despite over a decade of applied fMRI research the precise relationship the vascular signals in fMRI and the electrical activity of the brain is largely unknown. In this CEBRA application, we propose to complete development of our methods of simultaneous EEG and fMRI and to adapt these to the recording of extracellular potentials. We believe that we have come up with robust solutions for recording microVolt EEG signals in the presence of milliVolt MR-generated artifacts and are now prepared to enter a development phase for this technology during which we can complete the construction of apparatus appropriate for human research applications. It has long been clear that the problems of concurrent EEG and fMRI are similar to those in concurrent extracellular recording and fMRIas the sources of artifacts are essentially the same. In fact, the signal to noise ratio for the latter should be somewhat better. There are however, significant hurdles to overcome in studying and controlling the safety of such recordings, which are the focus of much of this grant proposal. We believe that this is an exceptionally significant project, in that these tools will enable us to perform crucial validation experiments that will be important in firming the very foundations on which the interpretation of functional MRI is based. Within the limited confines of the budget for the CEBRA program, the project will stop short of actual human experimentation with depth electrodes - the human work will be limited to scalp EEG to stay within the limited scope of the stage I mechanism. On its successful completion, the project will be followed immediately by an application for Stage II support to begin animal experimentation and shortly thereafter to initiate human studies.

功能性磁共振成像（fMRI）已成为人类认知和行为生理学研究的主要工具。然而，大脑内每时每刻的信号传输基本上都是电信号。尽管功能磁共振成像的应用研究已经进行了十多年，但功能磁共振成像中的血管信号与大脑电活动的精确关系在很大程度上还是未知的。在此 CEBRA 应用中，我们建议完成同步脑电图和功能磁共振成像方法的开发，并使这些方法适应细胞外电位的记录。我们相信，我们已经提出了在存在毫伏 MR 伪影的情况下记录微伏脑电图信号的强大解决方案，并且现在准备进入该技术的开发阶段，在此期间我们可以完成适合人类研究应用的设备的构建。人们早就清楚，并发脑电图和功能磁共振成像的问题与并发细胞外记录和功能磁共振成像的问题相似，因为伪影的来源本质上是相同的。事实上，后者的信噪比应该更好一些。然而，在研究和控制此类录音的安全性方面仍存在重大障碍需要克服，这也是本拨款提案大部分内容的重点。我们相信这是一个非常重要的项目，因为这些工具将使我们能够进行关键的验证实验，这对于巩固功能 MRI 解释的基础非常重要。在 CEBRA 计划预算的有限范围内，该项目将停止使用深度电极进行实际人体实验 - 人类工作将仅限于头皮脑电图，以保持在第一阶段机制的有限范围内。成功完成后，该项目将立即申请第二阶段支持，以开始动物实验，并随后不久启动人体研究。