Implications of OAE Cochlear Source Contribution

OAE 耳蜗源贡献的影响

• 批准号: 6935785
• 负责人: Tiffany A Johnson
• 金额: $ 4.4万
• 依托单位: FATHER FLANAGAN'S BOYS' HOME
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6935785
• 关键词: auditory discrimination; auditory stimulus; auditory threshold; clinical research; cochlea; diagnosis design /evaluation; diagnosis quality /standard; hearing; hearing disorders; hearing tests; human subject; otoacoustic emission; patient oriented research; perceptual maskings; postdoctoral investigator; sound frequency

Current thinking suggests that two cochlear sources contribute to distortion product otoacoustic emissions (DPOAEs), a distortion source and a reflection source. In contrast, low-level stimulus frequency OAEs (SFOAEs) are believed to be dominated by reflection-source contributions. It has been proposed that DPOAEs would more accurately predict behavioral threshold and identify auditory status if the reflection-source contribution is reduced or eliminated, although this hypothesis has not been tested. The broad objective of the proposed study is to determine the influence of cochlear-source contribution on OAE test performance. Four specific aims are posed. 1) The most effective suppressor tone for reducing the reflection-source contribution to DPOAEs will be determined. 2) Accuracy in predicting behavioral thresholds from traditional (two-source) DPOAEs, distortion-source DPOAEs (reflection source suppressed), and SFOAEs, will be evaluated in normal and impaired human ears. 3) Clinical decision theory will be used to evaluate the accuracy with which dichotomous decisions regarding auditory status are made with two-source (traditional DPOAEs) and single-source OAEs (distortion-source DPOAEs and SFOAEs). 4) The role of fine structure (thought to arise from the complex summation of distortion- and reflection-source energy for DPOAEs) in prediction and diagnostic errors will be evaluated.

目前的想法表明，两个耳蜗源会导致失真产物耳声发射（DPOAE），即失真源和反射源。相比之下，低水平刺激频率 OAE (SFOAE) 被认为主要由反射源贡献决定。有人提出，如果反射源贡献减少或消除，DPOAE 将更准确地预测行为阈值并识别听觉状态，尽管这一假设尚未得到检验。本研究的主要目标是确定耳蜗源贡献对 OAE 测试性能的影响。提出了四个具体目标。 1) 将确定用于减少反射源对 DPOAE 影响的最有效的抑制器音调。 2) 将在正常和受损的人耳中评估传统（双源）DPOAE、失真源 DPOAE（反射源抑制）和 SFOAE 预测行为阈值的准确性。 3) 临床决策理论将用于评估双源（传统 DPOAE）和单源 OAE（失真源 DPOAE 和 SFOAE）做出有关听觉状态的二分决策的准确性。 4) 将评估精细结构（被认为是由 DPOAE 的畸变和反射源能量的复杂求和产生）在预测和诊断误差中的作用。