Adult health consequences of childhood obesity

儿童肥胖对成人健康的影响

• 批准号: 6884982
• 负责人: JENNIFER Lyn BAKER
• 金额: $ 4.18万
• 依托单位: INSTITUTE OF PREVENTIVE MEDICINE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6884982
• 关键词: adolescence (12-20); body composition; cancer risk; cardiovascular disorder risk; clinical research; disease /disorder proneness /risk; epidemiology; human data; human morbidity; human mortality; middle childhood (6-11); morphometry; obesity; postdoctoral investigator

DESCRIPTION (provided by applicant): The goal of the proposed research is to develop better definitions of childhood overweight and obesity based on the association of childhood weight with health consequences in adulthood. Current definitions are based on a child having a value above an arbitrary cut-off in a distribution of weight or body mass index (BMI; kg/m2). Children in the US and worldwide are becoming excessively heavy at progressively younger ages. Therefore, it is both critical and timely that we examine the risks of excess weight and weight change in childhood for adult disease and create evidence based cut-offs. We will use data from the Copenhagen School Health Records Register, which is based on a population of school children born between 1930 - 1983 and contains computerized weight and height measurements on 351,777 boys and girls in the Copenhagen area. We will use survival analysis techniques to examine if childhood BMI and change in BMI from age 7-14 y is associated with an-increased risk of developing heart disease, cerebrovascular disease, obesity-related cancers and mortality in adulthood. Based on the association of childhood BMI with adult disease and mortality, we will develop criteria to define categories of childhood overweight and obesity.

描述（由申请人提供）：拟议的研究的目的是根据儿童体重与成年后的健康后果的关联，对童年超重和肥胖进行更好的定义。当前的定义是基于在重量或体重指数分布（BMI; kg/m2）中具有超过任意截止值的儿童。在美国和全球的儿童在年轻的年龄越来越大。因此，我们检查成人疾病的体重过剩和体重变化的风险既关键又及时，并创建了基于证据的截止。我们将使用哥本哈根学校健康记录登记册中的数据，该记录基于1930年至1983年之间出生的小学生，并包含哥本哈根地区351,777名男孩和女孩的计算机重量和身高测量。我们将使用生存分析技术来检查儿童期BMI和BMI的变化是否与患心脏病，脑血管疾病，与肥胖相关的癌症以及成年期的死亡风险有关。根据儿童期BMI与成人疾病和死亡率的关联，我们将制定标准来定义儿童期超重和肥胖类别。