Thiol-Ene Polymers as Dental Restorative Materials

硫醇烯聚合物作为牙科修复材料

• 批准号: 6999112
• 负责人: NEIL B CRAMER
• 金额: $ 4.91万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6999112
• 关键词: alkenes; biomaterial compatibility; biomaterial development /preparation; biotechnology; chemical stability; chemical synthesis; composite resins; dental materials; mechanical stress; monomer; polymers; postdoctoral investigator; restorative dentistry; thiols; toxicology

DESCRIPTION (provided by applicant): The proposed research is to develop thiol-ene polymers for application as dental restorative materials. The goals of this research are to develop thiol-ene materials that will have superior properties relative to current polymers utilized for dental restorative materials. The research will involve studying the relationship between chemical structure, polymerization kinetics, and material properties, these studies will be conducted with commercially available monomers and also novel thiol and ene monomers synthesized in the Bowman and Stansbury research groups. Thiol-ene based dental composite systems with filler particles will also be studied. Critical areas that will be addressed are volume shrinkage and shrinkage stress as well as the stability of the monomer formulations. The compatibility of monomer formulations with filler particles and the properties of filled systems will be evaluated. Biocompatibility of the new dental restorative materials will also be assessed.

描述（由申请人提供）：拟议的研究是开发用作牙科修复材料的硫醇-烯聚合物。这项研究的目标是开发硫醇烯材料，该材料相对于目前用于牙科修复材料的聚合物具有更优异的性能。该研究将涉及化学结构、聚合动力学和材料性能之间的关系，这些研究将通过 市售单体以及鲍曼和斯坦斯伯里研究小组合成的新型硫醇和烯单体。还将研究含有填料颗粒的硫醇烯基牙科复合材料系统。将要解决的关键领域是体积收缩和收缩应力以及单体配方的稳定性。将评估单体配方与填料颗粒的相容性以及填充系统的性能。新型牙科修复材料的生物相容性也将得到评估。