Speckle-Free Transmission Ultrasound for Breast Imaging

用于乳腺成像的无散斑透射超声

• 批准号: 6743498
• 负责人: SHIH-CHUNG B LO
• 金额: $ 43.15万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6743498
• 关键词: Speckle; Free; Transmission; Ultrasound; Breast

DESCRIPTION (provided by applicant): It is known that the inability to correctly identify breast cancer in women with glandular and dense breasts is in part due to the overlap in tissues at different depths that conceal contained masses. Dense breasts are most common in younger women. In this group the sensitivity of mammography is less. We propose to adapt a newly invented C-scan ultrasound technology to develop a tomographic system that potentially can improve the visualization of cancerous masses and abnormalities in dense breast tissues. The system proposed is a real-time C-scan transmission ultrasound camera. Unlike conventional ultrasound, the proposed system produces speckle-free images striking for their radiographic appearance. Conventional ultrasound creates images based on the speed of sound transmission through tissues. The proposed system creates its images based on the tissue attenuation of sound, a separate physical parameter that can provide new information about the breast since sound transmission speed and attenuation of sound are not closely correlated. In addition, the proposed system combines the advantages of traditional mammogram imaging with the ability of ultrasound to resolve soft tissue layers. Evaluation of the proposed system will be performed on three levels: a technical system evaluation using breast phantoms, in-vitro study using breast specimens, and an in-vivo study involving a population of a minimum of 50 patients. This project aims at the development of a novel clinically viable system tailored to imaging human breasts for screening, diagnostic, and biopsy procedures. We believe that the high quality, high-resolution images coupled with tomographic capability will decrease the number of breast cancers that are currently missed. Specific tasks completed as a part of R21 are (1) evaluation of the existing laboratory system with recommendations for adaptation to breast imaging and (2) fabrication of a clinical prototype suitable for use by clinical personnel. Tasks completed as a part of R33 are (1) verification of clinical viability through breast phantom, in-vitro, and in-vivo studies, (2) definition of clinical protocols for breast cancer screening and diagnosis, and (3) verification of suitability in image-guided breast tissue biopsy procedures.

描述（由申请人提供）： 众所周知，女性无法正确识别乳腺癌 具有腺体和致密乳房的部分原因是由于组织重叠 隐藏所含质量的不同深度。致密的乳房是最常见的 在年轻女性中。在这一组中，乳房X线照相术的敏感性较低。我们 建议采用新发明的 C 扫描超声技术来开发 断层扫描系统可能会改善癌症的可视化 致密乳腺组织中的肿块和异常。所提出的系统是一个 实时C扫描传输超声摄像机。与传统的不同 超声波，所提出的系统产生引人注目的无斑点图像 他们的放射线外观。传统超声波创建图像的基础是 声音通过组织传播的速度。拟议的系统创建 它的图像基于声音的组织衰减，一个单独的物理 自声音以来可以提供有关乳房新信息的参数 传输速度和声音的衰减并不密切相关。在 此外，所提出的系统结合了传统乳房X光检查的优点 具有超声解析软组织层能力的成像。 对拟议系统的评估将在三个层面上进行： 使用乳房模型进行技术系统评估，使用乳房进行体外研究 样本，以及涉及至少 50 人的体内研究 患者。该项目旨在开发一种新型的临床可行的 专为人类乳房成像以进行筛查、诊断和活检而定制的系统 程序。我们相信高质量、高分辨率的图像加上 具有断层扫描功能将减少乳腺癌的数量 目前已错过。作为 R21 的一部分完成的具体任务是 (1) 评估现有实验室系统并提出建议 适应乳腺成像和 (2) 制作临床原型 适合临床人员使用。作为 R33 的一部分完成的任务是 (1) 通过乳房模型、体外和体外验证临床可行性 体内研究，(2) 乳腺癌临床方案的定义 筛查和诊断，以及 (3) 图像引导适用性验证 乳腺组织活检程序。