Speckle-Free Transmission Ultrasound for Breast Imaging

用于乳腺成像的无散斑透射超声

• 批准号: 6743498
• 负责人: SHIH-CHUNG B LO
• 金额: $ 43.15万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6743498
• 关键词: Speckle; Free; Transmission; Ultrasound; Breast

DESCRIPTION (provided by applicant): It is known that the inability to correctly identify breast cancer in women with glandular and dense breasts is in part due to the overlap in tissues at different depths that conceal contained masses. Dense breasts are most common in younger women. In this group the sensitivity of mammography is less. We propose to adapt a newly invented C-scan ultrasound technology to develop a tomographic system that potentially can improve the visualization of cancerous masses and abnormalities in dense breast tissues. The system proposed is a real-time C-scan transmission ultrasound camera. Unlike conventional ultrasound, the proposed system produces speckle-free images striking for their radiographic appearance. Conventional ultrasound creates images based on the speed of sound transmission through tissues. The proposed system creates its images based on the tissue attenuation of sound, a separate physical parameter that can provide new information about the breast since sound transmission speed and attenuation of sound are not closely correlated. In addition, the proposed system combines the advantages of traditional mammogram imaging with the ability of ultrasound to resolve soft tissue layers. Evaluation of the proposed system will be performed on three levels: a technical system evaluation using breast phantoms, in-vitro study using breast specimens, and an in-vivo study involving a population of a minimum of 50 patients. This project aims at the development of a novel clinically viable system tailored to imaging human breasts for screening, diagnostic, and biopsy procedures. We believe that the high quality, high-resolution images coupled with tomographic capability will decrease the number of breast cancers that are currently missed. Specific tasks completed as a part of R21 are (1) evaluation of the existing laboratory system with recommendations for adaptation to breast imaging and (2) fabrication of a clinical prototype suitable for use by clinical personnel. Tasks completed as a part of R33 are (1) verification of clinical viability through breast phantom, in-vitro, and in-vivo studies, (2) definition of clinical protocols for breast cancer screening and diagnosis, and (3) verification of suitability in image-guided breast tissue biopsy procedures.

描述（由申请人提供）： 众所周知，无法正确识别女性的乳腺癌 腺体和浓密的乳房部分是由于组织在组织中的重叠 隐藏质量的不同深度。浓密的乳房最常见 在年轻妇女中。在这一组中，乳房X线摄影的敏感性较小。我们 建议适应新发明的C扫描超声技术以开发 层析成像系统可能会改善癌性的可视化 密集的乳房组织中的质量和异常。提出的系统是 实时C扫描超声摄像头。与传统不同 超声检查，提议的系统会产生无斑点的图像。 它们的影像学外观。传统超声创建基于 通过组织的声音传递速度。提出的系统创建 它的图像基于声音的组织衰减，一个单独的物理 可以提供有关乳房新信息的参数，因为声音 传输速度和声音的衰减不密切相关。在 此外，提出的系统结合了传统乳房X线照片的优势 具有超声解决软组织层的能力成像。 对拟议系统的评估将在三个级别上进行： 使用乳房幻象的技术系统评估，使用乳房的体外研究 标本和体内研究，涉及至少50的人群 患者。该项目旨在开发新颖的临床可行性 量身定制成像人乳房的系统，用于筛查，诊断和活检 程序。我们相信高质量的高分辨率图像耦合 具有断层扫描能力将减少乳腺癌的数量 目前错过了。作为R21的一部分完成的特定任务是（1） 评估现有实验室系统的建议 适应乳房成像和（2）制造临床原型 适用于临床人员使用。作为R33的一部分完成的任务是 （1）通过乳房幻影，体外和 体内研究，（2）乳腺癌临床方案的定义 筛查和诊断，以及（3）图像引导中适用性的验证 乳腺组织活检程序。