Sensorimotor Control of the Human Orofacial System

人类口面部系统的感觉运动控制

• 批准号: 6838747
• 负责人: STEVEN M BARLOW
• 金额: $ 40.65万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-15 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6838747
• 关键词: assistive device /technology; behavioral /social science research tag; biomechanics; developmental neurobiology; electromyography; electrophysiology; face; human subject; human therapy evaluation; infant human (0-1 year); intubation; longitudinal human study; mouth; neural plasticity; neuromuscular disorder; neuromuscular system; oral behavior; premature infant human; reflex; rehabilitation; respiratory disorder; respiratory system; sensorimotor system; sensory feedback; stimulus /response

DESCRIPTION (provided by applicant): The proposed studies are intended to expand our understanding of sensorimotor integration in the neonate and infant orofacial system during patterned oromotor output [non-nutritive suck -- NNS] using a servo-controlled ACTIFIER. Three specific aims have been formulated to investigate the sensorimotor apparatus of the neonate orofacial system using a novel electrophysiologic technique to index the excitability of trigeminofacial pathways during NNS in term and pre-term infants. The ability to modulate the organization of patterned oromotor output will be explored using mechanosensory entrainment, and finally, some principles of neuroplasticity will be tested in habilitating neonates in the intensive care nursery who manifest dysfunctional oromotor control. Simultaneous recordings of chest wall kinematics are included as a control measure to assess the nature and specificity of perioral stimulation on respiratory patterning. The proposed habilitation strategy, utilizing natural mechanical stimulation, has ecological validity in assisting the infant to produce an appropriate motor output. Moreover, this approach is consistent with the contention that appropriate oral experiences may be critical in the final weeks of gestation, and that their interruption may impair fragile syntheses of central neural representations of functions.

描述（由申请人提供）：拟议的研究旨在 扩展我们对新生儿和婴儿中感觉运动整合的理解 在图案化的Oromotor输出期间的口面系统[非脱节的吸吮-NNS] 使用伺服控制的Actifier。已经提出了三个具体目标 使用A的新生儿口面系统的感觉运动设备 新型的电生理技术，以索引三角形的兴奋性 NNS期间的途径和期前婴儿。调制的能力 将使用机械感觉探索图案化的Oromotor输出的组织 夹带，最后，将测试一些神经可塑性的原理 在重症监护仪式中的新生儿，表现功能失调 Oromotor控制。包括胸壁运动学的同时记录 作为评估围绕性质和特异性的控制措施 刺激呼吸模式。拟议的动力策略， 利用自然机械刺激，具有生态有效性 婴儿产生适当的电动机输出。而且，这种方法是 与适当的口头经历可能是一致的 在妊娠的最后几周至关重要，他们的中断可能 损害功能中心神经表示的脆弱合成。