Neuropeptides and Epilepsy Symposium

神经肽与癫痫研讨会

• 批准号: 6812863
• 负责人: MICHAEL J KUBEK
• 金额: $ 0.5万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6812863
• 关键词: anticonvulsants; corticotropin releasing factor; epilepsy; galanin; meeting /conference /symposium; neuropeptide Y; neuropeptides; somatostatin; substance P; thyrotropin releasing hormone; travel

DESCRIPTION (provided by applicant): Despite current advances in the treatment of epilepsy, intractable seizures and seizure-related complications remain a significant therapeutic challenge in neurology throughout the world. The neuropeptides, first characterized in neuroendocrine systems, have clearly demonstrated functions as potent neurotransmitters/neuromodulators outside the hypothalamus. Basic and clinical research begun in the early eighties revealed a distinct neuroanatomical distribution and neurochemical role for neuropeptides in seizure modulation. It has now become clear that certain neuropeptides have a strong association with seizures either as pro- or anti- convulsants. The goal of this inaugural symposium is to provide a forum for education and information exchange among professionals and students to better understand how such seizure-related neuropeptides may be developed as a new class of antiepileptic/antiepileptogenic compounds. Moreover, knowledge gained through collegial interactions could provide further insights into the pathophysiology and treatment of the intractable epilepsies. The symposium entitled "Neuropeptides and Epilepsy" is a component of the Annual American Summer Neuropeptide Conference, Miami Beach, Florida, July 5 - 9, 2004. This premier conference, now in its 14th year, highlights major new advances in neuropeptide research and attracts 125 to 150 participants from the US and abroad. Those contributing include junior and senior researchers from basic, clinical and pharmaceutical laboratories, postdoctoral fellows and advanced graduate students. Participation by women, minorities and researchers with disabilities is strongly encouraged. Topics to be covered in the symposium include the role of NPY, TRH, CRH, Galanin, Substance-P and Somatostatin in epilepsy. Receptor localization, pharmacology, and electrophysiology for each neuropeptide will be discussed. Preclinical and clinical studies will be presented where applicable. New technologies in neuropeptide delivery and in the use of genomic analysis in epilepsy will be presented. Knowledge gained from this first comprehensive meeting to address issues relative to neuropeptides and epilepsy along with the emergence of techniques to examine seizure-induced gene activation is compatible with the mission of the NINDS and will substantially impact epilepsy research and foster collaborations among the participants far into the future. The total amount requested is $8,850.

描述（由申请人提供）：尽管目前在治疗癫痫的治疗方面取得了进步，但顽固性的癫痫发作和与癫痫发作有关的并发症仍然是全球神经病学的重大治疗挑战。 首先在神经内分泌系统中表征的神经肽清楚地表明了下丘脑外的有效神经递质/神经调节剂。 基础和临床研究始于八十年代初期，揭示了神经化学在癫痫发作调节中的神经化学分布和神经化学作用。 现在已经很清楚某些神经肽与癫痫发作的癫痫发作有很强的联系。 首届研讨会的目的是为专业人士和学生之间的教育和信息交流论坛提供论坛，以更好地了解如何将这种与癫痫发作相关的神经肽作为新的抗癫痫/抗癫痫/抗癫痫剂化合物开发。 此外，通过联合互动获得的知识可以提供对顽固性癫痫病的病理生理学和治疗的进一步见解。 题为“神经肽和癫痫”的研讨会是2004年7月5日至9日，佛罗里达州迈阿密海滩的年度美国夏季神经肽会议的组成部分。这次首要会议（现已成立14年）凸显了神经肽研究的重大新进步，并吸引了我们和我们和我们和竞选的125至150名参与者。 贡献者包括来自基础，临床和制药实验室，博士后研究员和高级研究生的初级和高级研究人员。 强烈鼓励妇女，少数民族和残疾研究人员参与。 研讨会中要涵盖的主题包括NPY，TRH，CRH，Galanin，persance-P和生长抑素在癫痫中的作用。 将讨论每种神经肽的受体定位，药理学和电生理学。 在适用的情况下，将介绍临床前和临床研究。 将提出神经肽递送和在癫痫中使用基因组分析的新技术。 从第一次全面会议中获得的知识，即解决相对于神经肽和癫痫的问题，以及检查癫痫发作诱导的基因激活的技术的出现与NINDS的使命兼容，并将显着影响癫痫研究，并促进参与者之间未来的合作。 请求的总金额为$ 8,850。