Efficacy of Thin HA Coatings Produced by a Novel Process

采用新工艺生产的薄 HA 涂层的功效

• 批准号: 6785676
• 负责人: ERIC J TOBIN
• 金额: $ 60.74万
• 依托单位: SPIRE CORPORATION
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-15 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6785676
• 关键词: biomaterial compatibility; chemical structure; cold temperature; dental implants; dogs; hydroxyapatites; medical implant science; shear stress; surface coating; technology /technique development; tensile strength; titanium

DESCRIPTION: (provided by the applicant) This project is developing a new generation of calcium phosphate coatings for dental implants, in which film crystallinity is optimized for enhanced bioactivity and osseointegration. Phase I examined the hypothesis that optimal crystallinity leads to more rapid and stronger device fixation. Film crystallinities ranging from 30-90% were produced by a novel, low temperature deposition method and evaluated in a small animal model (rat). It was found that the ideal range was between 50-70% crystalline. These coatings provided bone-device integration compared to conventional plasma spray coatings. The purpose of the Phase II program is to further evaluate and demonstrate the advantage of calcium phosphate coatings with optimized crystallinity, as defined in Phase I. Both early and long-term bone response will be assessed in a large animal (canine) model, both prior to and after prosthesis loading. The desire to introduce this innovative technology to the field of dental implantology is based on two primary advantages of the process over existing technology used to apply HA coatings to implants. First, the chemical composition and crystallinity of the applied coating can be precisely controlled over a wide range of values, without the need for post deposition annealing. Second, the HA coatings can be deposited at low temperature as thin films from 1 to 5 mu/m thick, much thinner than coatings applied using plasma spray technology. Thinner coatings can provide a higher interfacial strength and better resistance than thicker plasma spray coatings.

描述：（由申请人提供）该项目正在开发用于牙种植体的新一代磷酸钙涂层，其中薄膜结晶度经过优化以增强生物活性和骨整合。第一阶段检验了最佳结晶度导致更快、更强的装置固定的假设。通过新颖的低温沉积方法生产了 30-90% 的薄膜结晶度，并在小动物模型（大鼠）中进行了评估。结果发现，理想的结晶度范围是 50-70%。与传统的等离子喷涂涂层相比，这些涂层提供了骨设备集成。 第二阶段计划的目的是进一步评估和证明具有优化结晶度的磷酸钙涂层的优势，如第一阶段所定义。早期和长期骨反应都将在大型动物（犬）模型中进行评估，假体装载之前和之后。将这项创新技术引入牙科种植领域的愿望是基于该工艺相对于用于将 HA 涂层应用于种植体的现有技术的两个主要优势。首先，所施加涂层的化学成分和结晶度可以在很宽的值范围内精确控制，而不需要沉积后退火。其次，HA涂层可以在低温下沉积为1至5μ/m厚的薄膜，比使用等离子喷涂技术涂覆的涂层薄得多。与较厚的等离子喷涂涂层相比，较薄的涂层可以提供更高的界面强度和更好的耐受性。