MATURATION, HYPOXIA AND AFFERENT FEEDBACK ON RESPIRATION

成熟、缺氧和呼吸传入反馈

• 批准号: 6537890
• 负责人: Metin Akay
• 金额: $ 26.9万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6537890
• 关键词: afferent nerve; aging; biofeedback; growth /development; hypoxia; mathematical model; model design /development; neural information processing; newborn animals; respiratory function; swine

DESCRIPTION: (Adapted from the Investigator's Abstract): The objective of this proposal is to generate data that can be useful in determining how system perturbations, such as hypoxia, gasping, and vagal and peripheral chemoreceptor activities, result in changes in respiratory patterns during maturation. The phrenic neurogram will be assessed as it exhibits features that reflect the dynamics of the phrenic respiratory pattern generator. The investigators will employ a technique known as non-linear neural dynamical analysis as a useful measure of quantifying the complexity of both physical systems and physiological signals. This will be applied to piglets at advancing postnatal ages during eupnea, before and after vagotomy, hypercapnia and hypoxic gasping, in the presence and absence of chemodenervation.

描述：（改编自研究者的摘要）：本研究的目的 建议是生成可用于确定系统如何使用的数据 扰动，例如缺氧、喘气、迷走神经和外周化学感受器 活动，导致成熟过程中呼吸模式的变化。这 将评估膈神经图，因为它表现出反映了 膈呼吸模式发生器的动力学。调查人员将 采用一种称为非线性神经动力学分析的技术作为有用的方法 量化物理系统和复杂性的衡量标准 生理信号。这将适用于产后后期的仔猪 平静呼吸期间、迷走神经切断术前后、高碳酸血症和缺氧喘息期间的年龄， 在存在和不存在化学去神经的情况下。