Individual differences in maternal behavior in the rat

大鼠母性行为的个体差异

基本信息

批准号：
6723742
负责人：
Michael Joseph Meaney
金额：
$ 13.5万
依托单位：
MCGILL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-08-20 至 2008-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6723742
关键词：
DARPP autoradiography behavior test behavioral /social science research tag behavioral genetics dopamine enzyme activity estrogen receptors estrogens fear gene environment interaction hormone inhibitor hormone sensitivity /resistance in situ hybridization laboratory rat maternal behavior mother child interaction neurotransmitter transport nucleus accumbens oxytocin phosphorylation preoptic areas protein kinase C receptor binding receptor expression western blottings

DARPP autoradiography behavior test behavioral /social science research tag behavioral genetics dopamine enzyme activity estrogen receptors estrogens fear gene environment interaction hormone inhibitor hormone sensitivity /resistance in situ hybridization laboratory rat maternal behavior mother child interaction neurotransmitter transport nucleus accumbens oxytocin phosphorylation preoptic areas protein kinase C receptor binding receptor expression western blottings

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项目摘要

DESCRIPTION (provided by applicant): Variations in maternal behavior regulate the development of neural systems that mediate the expression of behavioral and endocrine responses to stress in the rat (see Liu et al., Science, 1997; Caldji et al., 1998 PNAS), as well as maternal behavior (Francis et al, 1999). Recent findings (Francis et al, 1999) suggest that these effects provide an example of the behavioral transmission of traits from one generation to the next. The next question concerns the origins of these individual differences in maternal behavior. Our primary goal in these studies is to understand the neurobiological basis for the relationships that exist between environmental stimuli, individual differences in parental behavior and the development of behavioral and endocrine responses to stress. The hypothesis which drives this grant attempts to explain these environmental effects in terms of the development of neural systems underlying fearfulness as well as those which mediate parental care. The experiments proposed here are designed to address the three principle tenets of this hypothesis: 1) that individual differences in maternal behavior are inherited via a behavioral mode of transmission, 2) that variations in maternal care are associated with individual differences in neural systems that mediate the expression of maternal behavior, and 3) that the critical features of these systems involve estrogen-oxytocin interactions which, in turn, regulate dopamine activity. Specifically we propose that maternal care influences the development of estrogen receptor gene expression in the medial preoptic area, increasing the sensitivity of this structure to oxytocin and providing a basis for subsequent oxytocin-induced increases in dopamine release in the nucleus accumbens.

描述（由申请人提供）：孕产妇行为的变化调节神经系统的发展，这些神经系统介导了大鼠对压力的行为和内分泌反应的表达（参见Liu等，Science，1997; Caldji等，1998 PNAS）以及母体行为（Francis等，1999）。最近的发现（Francis等，1999）表明，这些影响提供了一个从一代到下一代的行为传播的例子。下一个问题涉及这些个体差异在孕产妇行为中的起源。在这些研究中，我们的主要目标是了解环境刺激，父母行为的个体差异以及行为和内分泌对压力的反应之间存在的关系的神经生物学基础。驱动这项赠款试图解释这些环境影响的假设是在恐惧和介导父母护理的神经系统发展方面的发展。 The experiments proposed here are designed to address the three principle tenets of this hypothesis: 1) that individual differences in maternal behavior are inherited via a behavioral mode of transmission, 2) that variations in maternal care are associated with individual differences in neural systems that mediate the expression of maternal behavior, and 3) that the critical features of these systems involve estrogen-oxytocin interactions which, in turn, regulate dopamine activity.具体而言，我们建议母体护理影响雌激素受体基因表达在内侧前区域中的发展，从而提高了该结构对催产素的敏感性，并为后续催产素诱导的多巴胺释放量的增加提供了基础。