MCLEAN STUDY OF ADULT DEVELOPMENT

麦克林成人发展研究

• 批准号: 6789453
• 负责人: MARY C ZANARINI
• 金额: $ 35.55万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6789453
• 关键词: behavior prediction; behavioral /social science research tag; borderline personality disorder; clinical research; comorbidity; developmental psychology; functional ability; health care service utilization; human subject; longitudinal human study; social psychology; young adult human (21-34)

The overall goal of this study is to continue a prospective study of the long-term course and outcome of borderline personality disorder (BPD). BPD is a common, symptomatically severe disorder associated with marked levels of psychosocial impairment and high levels of mental health and other social service utilization. Initial assessment data are available for a sample of 362 inpatients between the ages of 18 and 35; 290 borderline patients and 72 Axis II controls. In addition, the 95 percent of the surviving patients currently eligible for their 2, 4, and 6-year follow-up evaluations have been re-interviewed. The first specific aim is to prospectively assess the six, eight, and ten-year course and outcome of these patients. Four main aspects of the course and outcome will be studied: (1) severity of borderline symptoms, (2) impairment in psychosocial functioning, (3) prevalence of comorbid Axis I and Axis II disorders, and (4) type and amount of psychiatric and medical treatment received. The second specific aim is to determine the best predictive model for each of four outcomes: remission of BPD, recurrence of BPD, the attainment of good psychosocial functioning, and suicide. The third specific aim is to assess the pathways to health reported by those borderline patients who improve substantially. The fourth specific aim is to compare the predictive power of three models of BPD: the categorical model, the severity model of dimensionality, and the 5-Factor Model of dimensionality. Demographic data, social and vocational functioning, psychiatric and medical treatment, borderline symptoms, Axis I and Axis II comorbidity, life stress, basic aspects of temperament, and pathways to health will be assessed at each follow-up period by one of two masters level research assistants blind to all previously collected data. In addition, knowledgeable informants will be interviewed concerning each patient's psychosocial functioning, and medical, work, and school records will be collected and reviewed.

这项研究的总体目标是继续一项前瞻性研究 长期课程和边缘人格障碍（BPD）的结果。 BPD是一种常见的，有症状的严重疾病，与显着水平相关 心理障碍和高水平的心理健康和其他社会 服务利用。最初的评估数据可用于362样本 18至35岁之间的住院患者； 290例边缘患者和72个轴 II控件。此外，目前有95％的幸存患者 有资格获得2、4和6年的随访评估 重新浏览。第一个具体目的是前瞻性评估六个， 这些患者的八个，十年的课程和结果。四个主要方面 将研究课程和结果：（1）边界症状的严重程度， （2）心理社会功能的损害，（3）合并症轴的流行率I 和Axis II疾病，以及（4）精神病和医学的类型和数量 接受治疗。第二个具体目的是确定最佳预测 四个结果中的每一个模型：BPD的缓解，BPD的复发， 获得良好的社会心理功能和自杀。第三个特定 目的是评估这些边界患者报告的健康途径 谁改善了。第四个特定目的是比较预测 BPD的三种模型的功率：分类模型，严重性模型 维度和维度的5因子模型。人口统计数据， 社会和职业功能，精神病和医疗， 边缘症状，轴I和轴II合并症，生命压力，基本方面 气质和健康途径将在每次随访中评估 两位大师级研究助理之一的期间对所有以前视而不见 收集的数据。此外，知识渊博的线人将接受采访 关于每个患者的社会心理功能，医疗，工作以及 学校记录将被收集和审查。