BEHAVIORAL INTERVENTIONS FOR WOMEN WITH HIV/AIDS - NY

针对女性艾滋病毒/艾滋病患者的行为干预 - 纽约州

• 批准号: 6702285
• 负责人: Jonathan N. Tobin
• 金额: $ 64.5万
• 依托单位: CLINICAL DIRECTORS NETWORK, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2006-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6702285
• 关键词: HIV infections; behavioral /social science research tag; body physical activity; cognitive behavior therapy; comorbidity; depression; diet; female; functional ability; health behavior; human subject; human therapy evaluation; nutrition related tag; patient oriented research; safe sex /sex abstinence; substance abuse related disorder; therapy compliance; women' s health

The principal objective of this proposed multisite clinical trial is to continue efforts to develop the most effective combination of behavioral interventions to optimize the health status of the most neglected and understudied population affected by the AIDS epidemic in this country: poor women of color living with HIV/AIDS. Findings from the current study with this population affirm the utility of cognitive-behavioral stress management training combined with expressive-supportive therapy (CBSM+) in reducing distress (depression, ,anxiety) and denial, while improving social support, self-efficacy, coping skills and quality of life. The proposed study will extend these findings in seeking to determine whether exposure to CBSM+ can significantly improve the ability of the participants to take advantage of a health behavior change program encouraging the adoption and maintenance of healthier lifestyle behaviors (high levels of medication adherence, appropriate nutritional intake and physical activity, safer sexual practices and reduced substance use/abuse) essential for optimal health in the context of living with HIV/AIDS. A corollary objective will be to determine whether the proposed intervention program will be beneficial to less-acculturated segments of the affected population (i.e., non-English speaking women with HIV/AIDS) by establishing culturally- and linguistically-sensitive versions of the program in Spanish and Creole. To accomplish these objectives, the proposed Phase III multisite clinical trial described in two linked interactive research project grant applications (Miami- S. Weiss, P.I.; New York/New Jersey- J. Tobin, P.I.) will randomize 450 ethically diverse women living with HIV/AIDS in the three major epicenters for women (Miami:n=180; New York:n=180; New Jersey:n=90) into a group CBSM+ Condition and an individual psychoeducational comparison condition (Phase I). Following Phase I, participants will be randomized by group or cohort into a group `Healthier Lifestyles' skills training program or an individual health educational control condition (Phase II) devoted to improving medication adherence, nutrition, physical activity, safer sex and substance use reduction. Follow-up assessments will be carried out at 6, 12, and 24 months after treatment.

这项拟议的多站点临床试验的主要目标是继续努力发展行为干预措施的最有效组合，以优化该国受艾滋病流行病影响最多的人群的健康状况：艾滋病毒/艾滋病有色人种的贫穷妇女。当前研究中，该人群的发现确认了认知行为压力管理培训的实用性，并在减少困扰（抑郁症，焦虑症）和拒绝的同时，在改善社会支持，自我效能，应对能力和生活质量的同时，结合了表现力支持治疗（CBSM+）。拟议的研究将扩展这些发现，以确定对CBSM+的接触是否可以显着提高参与者利用健康行为变化计划的能力，以鼓励采用和维持更健康的生活方式行为（高度的药物依从性，适当的营养摄入和适当的营养摄入和身体活动，更安全的性行为，更安全的性行为，更安全的性行为和滥用滥用的生活）。必然的目标是确定拟议的干预计划是否将对受影响人群的较少养殖（即，具有艾滋病毒/艾滋病的非英语妇女）建立在西班牙和克里奥尔语中的文化和语言敏感版本，来确定受影响人群的细分（即，艾滋病毒/艾滋病的非英语妇女）。 To accomplish these objectives, the proposed Phase III multisite clinical trial described in two linked interactive research project grant applications (Miami- S. Weiss, P.I.; New York/New Jersey- J. Tobin, P.I.) will randomize 450 ethically diverse women living with HIV/AIDS in the three major epicenters for women (Miami:n=180; New York:n=180; New Jersey:n=90) into a group CBSM+条件和个体的心理教育比较条件（I期）。在第一阶段之后，参与者将通过小组或队列随机分为“健康生活方式”技能培训计划或个人健康教育控制条件（II期），该条件（II期）致力于改善药物依从性，营养，体育锻炼，更安全的性和物质使用减少。后续评估将在治疗后6、12和24个月进行。