AUSTRALASIAN COLORECTAL CANCER FAMILY REGISTRY

澳大利亚结直肠癌家族登记处

• 批准号: 6798340
• 负责人: JOHN L HOPPER
• 金额: $ 118.43万
• 依托单位: UNIVERSITY OF MELBOURNE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-24 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6798340
• 关键词: Australia; DNA methylation; New Zealand; bioinformatics; cancer registry /resource; cancer risk; clinical research; colorectal neoplasms; cooperative study; family genetics; gene environment interaction; genetic susceptibility; human genetic material tag; human population study; human subject; informatics; lifestyle; longitudinal human study; neoplasm /cancer epidemiology; neoplasm /cancer genetics; questionnaires; sample collection; statistics /biometry; tissue resource /registry

DESCRIPTION (provided by applicant): The specific aim of this Australasian center-specific proposal is to renew activities as part of a six-center consortium known as the Cooperative Family Registry(CFR) for colorectal cancer. The aim of the CFR is to accrue colorectal cancer families according to a protocol that includes the generation of a repository of biospecimens (blood and tumour samples),and comprehensive lifestyle data obtained through standardized epidemiologic questionnaires, so as to support research from groups within and outside the CFR. To achieve this, over the next five years we will: 1. Recruit 320 population-based colorectal cancer cases diagnosed before the age of 50, regardless of family history,and 250 clinic-based families with at least three cases, as part of the Accrual Component. 2. Not contribute to the Minorities Component. 3. Conduct follow-up activities with all subjects(except controls and relatives of controls)who consented to be participants in the CFR during the first phase of recruitment and data collection(July 1997 - July2002), as well as all new participants who will be recruited in Year 01 to 04 of the renewal in 1. above. We plan both active follow-up at 4 and 6 years after original enrolment, and annual passive follow-up, including a Newsletter. We estimate that our follow-up will involve 10,217 individuals in 1,356 families. 4. Participate in the Molecular Characterization Component by contributing appropriate samples to GMP and the participating CFR laboratories. We estimate that we will prepare, ship, and track samples as follows:556 for DNA sequencing,856 for methylation, and 126 samples for GMP conversion mutation analysis. 5. Maintain the biospecimens repository comprising blood samples and tumor blocks and/or paraffin sections and respond to approved requests for samples. 6. Maintain our bioinformatics support activities so that we can respond to queries from CFR and non-CFR investigators, support local analyses, and coordinate activities with the Informatics Support Center (ISC). 7. Develop and maintain a fresh frozen tissue repository on selected, newly diagnosed cases that will contain tissues from 30 colorectal cancers or polyps obtained per year from subjects treated within Queensland. 8. Conduct Pilot studies that will continue the innovative molecular and pathology work by Professor Jass and his laboratory to further unravel the genetic heterogeneity of hereditary colorectal cancer. We shall use the results of the statistical Pilot Study to develop the machinery for analyzing the accrued data, make blood collection and extension of families more efficient and informative, and provide a better resource for future gene discovery.

描述（由申请人提供）： 这个澳大利亚中心特定建议的具体目的是续订 活动是六个中心财团的一部分，称为合作家族 结直肠癌的注册表（CFR）。 CFR的目的是累积 结直肠癌家族根据包括 生成生物测量的存储库（血液和肿瘤样品），以及 通过标准化流行病学获得的全面生活方式数据 问卷，以支持来自内外的小组的研究 CFR。为了实现这一目标，在接下来的五年中，我们将： 1。招募320例基于人群的结直肠癌病例 50岁，无论家族史如何，有250个基于诊所的家庭 至少三个情况，作为应计成分的一部分。 2。不为少数族裔组成。 3。与所有受试者进行后续活动（对照和除外 控件的亲属）在同意期间同意参加CFR的参与者 招聘和数据收集的第一阶段（1997年7月至2002年7月） 作为所有新参与者，他们将在续约的01至04年招募 在上面的1。我们计划在原始后4年和6年进行积极的随访 入学率和年度被动后续行动，包括新闻通讯。我们估计 我们的后续行动将涉及1,356个家庭中的10,217个人。 4。通过贡献参与分子表征成分 适合GMP和参与CFR实验室的样本。我们估计 我们将准备，运送和跟踪样本如下：556用于DNA 测序，856用于甲基化和126个用于GMP转换突变的样品 分析。 5。维持包含血液样本和肿瘤的生物测量存储库 块和/或石蜡部分，并响应批准的样品请求。 6.维护我们的生物信息学支持活动，以便我们可以回应 CFR和非CFR研究人员的查询，支持本地分析，以及 与信息学支持中心（ISC）协调活动。 7。在选定的新近开发和维护新鲜的冷冻组织存储库 诊断出将包含30种结直肠癌或息肉的组织的病例 每年从昆士兰州境内治疗的受试者获得。 8。进行试点研究，以继续创新的分子和 Jass教授及其实验室的病理学工作，以进一步阐明 遗传性结直肠癌的遗传异质性。我们将使用 统计试点研究的结果是开发用于分析的机械的结果 应计数据，使家庭的血液收集和扩大更多 高效且信息丰富，并为未来的基因提供更好的资源 发现。