Oleic Acid Effects on Transit and Absorption in SBS

油酸对 SBS 转运和吸收的影响

• 批准号: 6765162
• 负责人: Charlene W Compher
• 金额: $ 14.89万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6765162
• 关键词: breath tests; clinical research; clinical trials; diarrhea; diet therapy; dietary supplements; dosage; feces analysis; gastrointestinal motility /pressure; gastrointestinal nutrient absorption; human subject; human therapy evaluation; malnutrition; nutrient intake activity; nutrition related tag; oleate; parenteral feedings; patient oriented research; quality of life; short bowel syndrome; weight gain

DESCRIPTION (provided by applicant): Short bowel syndrome (SBS) results from extensive resection of the small intestine +/- the colon, due to disease. Malnutrition ensues as a result of malabsorption and is treated with total parenteral nutrition (TPN). Patients with severe SBS remain chronically dependent on TPN with its attendant risks, yet must cope with debilitating diarrhea. Long-chain fatty acids (such as oleic acid) in the intestinal lumen slow transit in more proximal bowel in normal subjects and patients with chronic diarrhea. This delay in transit, if it occurs in SBS and is sustained, could enhance digestion and absorption of nutrients and defray the need for TPN. The primary aims of the proposed investigation are: 1. To determine in a dose-response trial the dose of preprandial oleic acid that will be acceptable to patients with SBS, and that will result in slowing of intestinal transit time. 2. To determine by a randomized double-blind placebo-controlled crossover pilot trial the patient burden, and the effect size of oleic acid treatment on transit time, nutrient absorption and quality of life. The long-term objectives of the proposed line of investigation are to improve the nutritional care and quality of life of patients with SBS. If the oleic acid treatment proves promising in the current pilot study, a larger multi-center trial (to include pediatric patients) will be designed to evaluate transit, micro- and macro-nutrient absorption, nutritional status, quality of life, and growth (children).

描述（由申请人提供）： 短肠综合征 (SBS) 是由于疾病导致小肠 +/- 结肠广泛切除所致。吸收不良会导致营养不良，可采用全肠外营养 (TPN) 进行治疗。患有严重 SBS 的患者仍然长期依赖 TPN 及其伴随的风险，但必须应对使人衰弱的腹泻。在正常人和慢性腹泻患者中，肠腔中的长链脂肪酸（例如油酸）在更近端的肠道中缓慢运输。如果这种运输延迟发生在 SBS 中并持续下去，可能会增强营养物质的消化和吸收，并满足 TPN 的需求。 拟议调查的主要目的是： 1. 在剂量反应试验中确定 SBS 患者可接受的餐前油酸剂量，该剂量将导致肠道传输时间减慢。 2. 通过随机双盲安慰剂对照交叉试验确定患者负担以及油酸治疗对转运时间、营养吸收和生活质量的影响大小。 拟议研究的长期目标是改善 SBS 患者的营养护理和生活质量。如果油酸治疗在当前的试点研究中被证明是有希望的，那么将设​​计一项更大规模的多中心试验（包括儿科患者）来评估转运、微量和大量营养素的吸收、营养状况、生活质量和生长。孩子们）。