CELL ASSEMBLIES, PHASE SEQUENCES AND MEMORY DYNAMICS

单元组件、相序和内存动态

• 批准号: 6530800
• 负责人: BRUCE L MCNAUGHTON
• 金额: $ 9.66万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6530800
• 关键词: electrodes; experience; hippocampus; laboratory rat; long term memory; memory; neocortex; neural information processing; psychological models; short term memory; sleep; stereotaxic techniques

DESCRIPTION (Adapted from applicant's abstract): This is an application for a K05, Senior Scientist Award. Throughout his career, the candidate has pursued the neurobiological and computational basis of memory. In the late 1970's, he provided the first evidence for the biological realization of Hebb's neurophysiological postulate for associative memory, by showing that synaptic long-term potentiation (LTP) in the hippocampus involved the cooperation of converging inputs. Since then, he has made numerous contributions to understanding the process of LTP at both the biophysical and behavioral levels, and contributed significantly to the development of neural network theories of both memory and the neural encoding of spatial information (cognitive maps). Motivated by the idea that memories are properties of neural populations, supported by enhanced mutual connections, the candidate has guided the development of methods that currently routinely enable recording simultaneously from over 100 neurons in the freely behaving rodent. This method has opened an unprecedented window on neuron interactions and has provided strong indirect evidence for the existence of Hebb's "cell assemblies" and "phase sequences" during a process of off-line reprocessing of recent memories in the hippocampus and neocortex. The candidate is currently Director of the Division of Neural Systems, Memory, and Aging, at the University of Arizona, a 9,000 sq. ft. research facility dedicated to memory research. The facility includes dedicated surgical, neuroanatomical and electronics engineering suites, and several specially designed controlled environments for behavioral neurophysiology. The candidate's own research team includes 5 postdoctoral, 6 graduate, and 4 undergraduate research associates, and 5 electronics, computer, and neurophysiological research specialists. The candidate's immediate and long term research goal is to understand the brain dynamics underlying the transformation of episodic memory into categorical knowledge, a process known as memory consolidation. The specific career development plan to be supported by this award is to begin to develop the technology to enable recording from up to 400 cells from the cortex and hippocampus in the behaving primate and to develop new analytical tools for understanding the behavior of cell assemblies in terms of these large populations of recorded units. The specific research projects deal with the questions of the reactivation of memory traces during sleep, how this is orchestrated by the hippocampus, and whether the process itself is truly of behavioral significance.

描述（改编自申请人的摘要）：这是一份申请 K05，高级科学家奖。 在他的整个职业生涯中，候选人 追求记忆的神经生物学和计算基础。 在后期 1970年代，他为生物实现提供了第一个证据 赫布关于联想记忆的神经生理学假设表明 海马突触长时程增强（LTP）涉及 汇聚投入的合作。 自此之后，他创作了无数 对理解 LTP 过程在生物物理学和生物物理学方面的贡献 和行为水平，并为发展做出了重大贡献 记忆和空间神经编码的神经网络理论 信息（认知地图）。 受到“记忆是”这个想法的启发 神经群体的特性，在增强的相互联系的支持下， 候选人指导了目前常规方法的开发 能够同时记录 100 多个神经元的自由行为 啮齿动物。 该方法为神经元研究打开了一扇前所未有的窗口 相互作用，并为相互作用的存在提供了强有力的间接证据。 赫布在离线过程中的“细胞组装”和“相序” 海马体和新皮质中最近记忆的再处理。 这 候选人目前是神经系统、记忆、 和老龄化，位于亚利桑那大学，占地 9,000 平方英尺的研究设施 致力于记忆研究。 该设施包括专用手术、 神经解剖学和电子工程套件，以及一些特殊的 为行为神经生理学设计受控环境。 这 候选人自己的研究团队包括5名博士后，6名研究生，4名 本科生研究员，以及 5 名电子、计算机和 神经生理学研究专家。 候选人的即时和长期 术语研究的目标是了解大脑的动态 情景记忆转化为分类知识的过程 称为记忆巩固。 具体的职业发展规划 该奖项的支持是开始开发技术以实现 记录来自大脑皮层和海马体的多达 400 个细胞 灵长类动物的行为并开发新的分析工具来理解 根据这些记录的大量细胞群的行为 单位。 具体的研究项目涉及以下问题： 睡眠期间记忆痕迹的重新激活，这是如何由 海马体，以及这个过程本身是否真的是行为的 意义。