Novel mandibular bone transport reconstruction plate

新型下颌骨骨运输重建板

• 批准号: 6690268
• 负责人: LYNNE A. OPPERMAN
• 金额: $ 22.51万
• 依托单位: CUSTOM SCIENTIFIC
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-06 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6690268
• 关键词: biomaterial development /preparation; biomechanics; biomedical equipment development; bone fracture; bone plates; bone transplantation; dental implants; dental materials; goats; mandible /maxilla; medical implant science; osteogenesis

DESCRIPTION: Surgical excision of hard and soft tissues of the head and neck or high impact trauma can lead to lead to major tissue deficits. Reconstruction of the lower jaw typically involves bone, gingiva, and teeth. Current mandibular distraction devices are used in combination with reconstruction plates, but while the reconstruction plates take the contour of the jaw, the distraction devices have a linear vector. The devices also have a limited distraction distance, producing short segments of straight bone and so cannot accommodate large deficits with a single procedure. The size of the combined apparatus makes it impossible to move dentate bone segments. Extra-oral devices function both as external fixator and bone transport distraction devices, with which it is possible to re-build the mandibular parasymphysis and chin. Nevertheless, the newly formed mandible is retruded due to soft tissue pressure and normal curvature of the mandible is not achieved. The objective of this application is to build and test prototypes of an intra-oral mandibular distraction device that will serve as a combined reconstruction plate and bone-transport device. This device will enable transport of dentate bone segments over large distances and prevent the inhibitions of form created by the soft tissues. The purpose of this device is to allow immediate reconstruction of mandibular bone following surgical excision, eliminating the need for bone grafting or secondary reconstruction. The device will enable regaining the same mechanical integrity and shape of the original mandible, without adding to the difficulty, duration, or complication of surgeries. Critical features of the device are that it functions both as a rigid mandibular reconstruction plate and a bone transport distraction device. The device is not limited by the size, shape, or location of the bone gap and because of the low position of the device; the transport disc can safely carry viable teeth without injuring the roots during fixation. The "check-point osteotomy" technique will make it possible for the first time to regain the normal curvature or the original mandible, and preserve the original lower facial dimensions as the traction force exerted by the soft tissue over the transport disc is rigidly shielded by the transport plate.

描述：头颈部硬组织和软组织的手术切除或高冲击力创伤可能导致主要组织缺损。下颌的重建通常涉及骨骼、牙龈和牙齿。目前的下颌牵引装置与重建板结合使用，但是当重建板采用下颌轮廓时，牵引装置具有线性矢量。这些设备的牵引距离也有限，会产生短段的直骨，因此无法通过单次手术来弥补大的缺陷。组合装置的尺寸使得齿状骨段不可能移动。口外装置既可用作外固定器，又可用作骨运输牵引装置，可以重建下颌副联合和下巴。然而，新形成的下颌骨由于软组织压力而后缩，无法实现下颌骨的正常曲率。该应用的目的是构建并测试口内下颌牵引装置的原型，该装置将用作组合重建板和骨传输装置。该装置将能够长距离运输齿状骨段，并防止软组织产生的形状抑制。该装置的目的是允许手术切除后立即重建下颌骨，从而消除骨移植或二次重建的需要。该装置将能够恢复与原始下颌相同的机械完整性和形状，而不会增加手术的难度、持续时间或复杂性。该装置的关键特征是它既可用作刚性下颌重建板，又可用作骨运输牵引装置。该装置不受骨间隙的尺寸、形状或位置的限制，并且由于装置的位置较低；运输盘可以安全地携带活牙，而不会在固定过程中损伤牙根。 “检查点截骨术”技术将首次使恢复正常曲率或原始下颌骨成为可能，并保留原始下面部尺寸，因为软组织对传送盘施加的牵引力被刚性屏蔽。运输板。

项目成果

Dentate transport discs can be used to reconstruct large segmental mandibular defects.

• DOI: 10.1016/j.joms.2014.12.002
• 发表时间: 2015-04
• 期刊: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
• 作者: Elsalanty ME;Malavia V;Zakhary I;Mulone T;Kontogiorgos ED;Dechow PC;Opperman LA
• 通讯作者: Opperman LA

Bone regeneration and docking site healing after bone transport distraction osteogenesis in the canine mandible.

犬下颌骨运输牵张成骨后的骨再生和对接部位愈合。

• DOI: 10.1016/j.joms.2011.02.016
• 发表时间: 2012
• 期刊: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
• 作者: Nagashima,LucyK;Rondon-Newby,Michelle;Zakhary,IbrahimE;Nagy,WilliamW;Zapata,Uriel;Dechow,PaulC;Opperman,LynneA;Elsalanty,MohammedE
• 通讯作者: Elsalanty,MohammedE

Biomechanical configurations of mandibular transport distraction osteogenesis devices.

• DOI: 10.1089/ten.teb.2009.0502
• 发表时间: 2010-01
• 期刊: Tissue engineering. Part B, Reviews
• 作者: U. Zapata;M. Elsalanty;P. Dechow;L. Opperman

Osseointegration of dental implants placed into canine mandibular bone regenerated by bone transport distraction osteogenesis.

植入犬下颌骨的牙种植体的骨整合通过骨运输牵引成骨进行再生。

• DOI: 10.11607/jomi.2977
• 发表时间: 2013
• 期刊: The International journal of oral & maxillofacial implants
• 作者: Kontogiorgos,Elias;Elsalanty,MohammedE;Zakhary,Ibrahim;Nagy,WilliamW;Dechow,PaulC;Opperman,LynneA
• 通讯作者: Opperman,LynneA

Three-dimensional evaluation of mandibular bone regenerated by bone transport distraction osteogenesis.

• DOI: 10.1007/s00223-011-9492-2
• 发表时间: 2011-07
• 期刊: CALCIFIED TISSUE INTERNATIONAL
• 影响因子: 4.2
• 作者: Kontogiorgos, Elias;Elsalanty, Mohammed E.;Zapata, Uriel;Zakhary, Ibrahim;Nagy, William W.;Dechow, Paul C.;Opperman, Lynne A.
• 通讯作者: Opperman, Lynne A.