SES, health behaviors and CVD among Vietnam-era-Twins

越南时代双胞胎的社会经济地位、健康行为和心血管疾病

• 批准号: 6724414
• 负责人: Jeanne M McCaffery
• 金额: $ 21.02万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6724414
• 关键词: behavioral /social science research tag; biomedical registry /referral center; cardiovascular disorder; cardiovascular disorder epidemiology; cardiovascular disorder risk; clinical research; disease /disorder etiology; gene environment interaction; generation difference; genetic susceptibility; health behavior; human data; human mortality; human subject; male; posttraumatic stress disorder; socioeconomics; statistics /biometry; twin /multiplet; veterans

DESCRIPTION (provided by applicant): Cardiovascular disease (CVD) affects approximately 60,800,000 Americans each year, claiming the lives of nearly one million of these people (American Heart Association, 2001). CVD is likely to be complex in etiology, reflecting the combined effect of both genes and environment, as well as gene x gene and gene x environment interaction. Examination of environmental factors thought to affect CVD risk in the context of a genetically informative design can help elucidate the relative contribution of genetic and environmental factors and potentially aid in identifying environmental factors that may interact with genetic vulnerability in predicting CVD. Cardiovascular morbidity and mortality are over-represented among individuals in lower socioeconomic strata, as are behaviors that increase the likelihood of cardiovascular events, including smoking, heavy alcohol consumption and physical inactivity (Adler et al., 1994; Anderson & Armstead, 1995). Thus, it is commonly assumed that socioeconomic status (SES) serves as an important environmental influence on health and health behaviors. Twin studies partition genetic and environmental variance and detect gene x environment interaction and provide a unique opportunity to study the association between SES and health. The goal of this application is to further characterize the nature of the association between SES, health behaviors and early CVD in the Vietnam Era Twin (VET) Registry, a sample of over 4,000 twin pairs. Specifically, we plan to: 1) determine how strongly environmental factors contribute to individual differences in SES, health behaviors and CVD, relative to genetic factors; 2) examine whether measures of SES are associated with health behaviors and CVD mortality when controlling for concomitant genetic influences; and 3) investigate whether SES interacts with genetic vulnerabilities to predict health behaviors and CVD (gene x environment interaction). The primary method of analysis will be twin structural equation modeling.

描述（由申请人提供）：心血管疾病（CVD）每年影响约60,800,000名美国人，夺走了近一百万这些人的生命（American Heart Association，2001年）。 CVD在病因学中可能很复杂，反映了基因和环境的综合作用，以及基因X基因和基因X环境相互作用。在遗传信息丰富的设计背景下，认为会影响CVD风险的环境因素的检查可以帮助阐明遗传和环境因素的相对贡献，并有助于识别可能与遗传脆弱性相互预测的环境因素。在较低的社会经济阶层的个体中，心血管发病率和死亡率过高，增加了心血管事件可能性的行为，包括吸烟，大量酒精消费和身体不活跃（Adler等人，1994年； Anderson＆Armstead，1995年）。因此，通常认为社会经济地位（SES）是对健康和健康行为的重要环境影响。双研究分配遗传和环境方差并检测基因X环境相互作用，并为研究SES与健康之间的关联提供了独特的机会。该应用的目的是进一步描述越南时代双（VET）注册表中SES，健康行为和早期CVD之间关联的性质，该注册表的样本超过4,000个双胞胎。具体而言，我们计划：1）确定与遗传因素相对于SES，健康行为和CVD的个体差异的强烈影响； 2）检查SES的测量是否与健康行为和CVD死亡有关，以控制伴随遗传影响； 3）研究SES是否与预测健康行为和CVD的遗传脆弱性相互作用（基因X环境相互作用）。分析的主要方法将是双结构方程建模。