N-ACETYLCYSTEINE AS TREATMENT IN COCAINE ADDICTION

N-乙酰半胱氨酸治疗可卡因成瘾

• 批准号: 6837325
• 负责人: STEVEN DAVID LAROWE
• 金额: $ 4.73万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2005-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6837325
• 关键词: acetylcysteine; clinical research; clinical trial phase I; cocaine; craving; cues; drug abuse chemotherapy; drug addiction; drug addiction antagonist; drug screening /evaluation; drug withdrawal; heart rate; human subject; human therapy evaluation; laboratory rat; patient oriented research; postdoctoral investigator; questionnaires; self medication; substance abuse related behavior

DESCRIPTION (provided by applicant): Recent findings have suggested that N-acetylcysteine (NAC) substantially reduces cocaine-primed drug-seeking behavior in formerly cocaine-dependent rats. The present proposal involves two components that simultaneously examine the impact of NAC within cocaine-dependent humans and rodents. The first component is an inpatient study that involves two 3-day hospital stays in which subjects receive either 4 doses of NAC or placebo. Subjects will undergo a cue reactivity procedure during their stay. It is predicted that cocaine-dependent individuals will show greater reactivity to cocaine cues during placebo relative to controls. It is predicted that NAC will reduce this cue reactivity in cocaine-dependent individuals. The second component examines the extent to which NAC reduces cocaine-seeking behavior in rodents and is designed to closely emulate the experimental conditions of clinical trials involving humans. Rats will receive access to cocaine via lever press. They will then be withdrawn from cocaine administration for an extended time, then reintroduced to free access to either saline or cocaine. Half will be treated with NAC prior to the free access period. It is proposed that NAC will reduce cocaine-seeking behavior.

描述（由申请人提供）： 最近的研究结果表明，N-乙酰半胱氨酸（NAC）大大减少了以前可卡因依赖的大鼠的可卡因引发的药物寻求行为。目前的提案涉及两个部分，同时检查 NAC 对可卡因依赖的人类和啮齿动物的影响。第一个组成部分是一项住院研究，涉及两次为期 3 天的住院治疗，其中受试者接受 4 剂 NAC 或安慰剂。受试者在逗留期间将接受提示反应程序。据预测，与对照组相比，可卡因依赖者在安慰剂期间将对可卡因线索表现出更大的反应性。据预测，NAC 将降低可卡因依赖者的这种提示反应性。第二部分研究 NAC 在多大程度上减少了啮齿动物的可卡因寻求行为，并旨在密切模拟涉及人类的临床试验的实验条件。老鼠将通过按下杠杆来获取可卡因。然后，他们将在较长时间内停止使用可卡因，然后重新开始自由使用盐水或可卡因。一半将在免费访问期之前接受 NAC 处理。建议 NAC 将减少寻求可卡因的行为。