Effects of Estrogen and Cannabinoids on Learning

雌激素和大麻素对学习的影响

基本信息

批准号：
6515884
负责人：
JILL M DANIEL
金额：
$ 1.35万
依托单位：
LSU HEALTH SCIENCES CENTER
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-04-01 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/6515884
关键词：
autoradiography behavioral /social science research tag behavioral habituation /sensitization brain cannabinoid receptor cannabinoids central nervous system estrogens hippocampus hormone regulation /control mechanism hormone therapy laboratory rat learning memory ovariectomy performance receptor binding

项目摘要

DESCRIPTION (provided by applicant) There is growing evidence to indicate that there is an interaction between the biologically active constituent of marijuana, delta 9-tetrahydrocannabinol (delta 9-THC), and the ovarian hormone, estrogen, in the central nervous system. However, little information is currently available regarding the functional consequences of this interaction on behavior. Additionally, despite the fact that the behavioral effects of other drugs of abuse are influenced by estrogenic status, the behavioral effects of delta 9-THC in female animal models have not been investigated. The experiments in the proposed study will test the following hypotheses: 1) Estrogen replacement will attenuate the disruptive effects of systemically administered delta 9-THC on overall response rate and percent errors in ovariectomized rats responding under a multiple schedule of repeated acquisition and performance of behavioral chains. 2) Estrogen replacement will differentially affect levels of cannabinoid receptor binding, as measured by quantitative receptor autoradiography, in brain areas implicated in learning and memory and will potentiate decreases in cannabinoid receptor binding induced by chronic administration of delta 9-THC. 3) Estrogen replacement will accelerate the development of delta 9-THC-induced behavioral tolerance in ovariectomized rats responding under a multiple schedule of repeated acquisition and performance of behavioral chains. 4) Estrogen replacement will attenuate the disruptive effects of intrahippocampally-administered delta 9-THC on overall response rate and percent errors in ovariectomized rats responding under a multiple schedule of repeated acquisition and performance of behavioral chains. These results will provide, for the first time, information regarding the interactive effects of estrogen and delta 9-THC on behavior.

描述（由申请人提供）越来越多的证据表明，两者之间存在相互作用。大麻的生物活性成分，δ9-四氢大麻酚（δ 9-THC），以及中枢神经中的卵巢激素、雌激素系统。然而，目前关于该问题的信息很少这种相互作用对行为的功能性影响。此外，尽管事实上，其他滥用药物的行为影响受到以下因素的影响：雌激素状态，Delta 9-THC 对雌性动物的行为影响模型尚未被研究。拟议研究中的实验将检验以下假设： 1) 雌激素替代疗法会减弱全身施用 delta 9-THC 对总体反应的破坏性影响卵巢切除大鼠在多重反应下的反应率和百分比错误行为链的重复获取和表现的时间表。 2）雌激素替代会不同程度地影响大麻素受体的水平通过定量受体放射自显影术测量大脑区域的结合与学习和记忆有关，并会增强大麻素的减少长期施用 delta 9-THC 诱导的受体结合。 3）雌激素替代将加速 delta 9-THC 诱导的行为的发展卵巢切除大鼠在多种方案下的耐受性行为链的重复获取和表现。 4）雌激素更换将减弱破坏性影响海马内注射 delta 9-THC 对总体反应率和卵巢切除大鼠在多种方案下反应的错误百分比行为链的重复获取和表现。这些结果将首次提供有关互动效果的信息雌激素和 delta 9-THC 对行为的影响。