Bipolar Disorder Across the Life Span

贯穿一生的双相情感障碍

• 批准号: 6797818
• 负责人: JOSEPH R CALABRESE
• 金额: $ 54.29万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-03 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6797818
• 关键词: behavioral /social science research tag; biomedical facility; bipolar depression; clinical research; community mental health services; comorbidity; developmental psychology; educational resource design /development; functional ability; health education; health science research; human subject; human therapy evaluation; life cycle; longitudinal human study; medically underserved population; mental disorder chemotherapy; outcomes research; patient care management; patient oriented research; psychometrics; substance abuse related disorder; therapy compliance

DESCRIPTION (provided by applicant): Bipolar disorder (BPD) affects a minimum of 2.3 million American adults aged 18 and older (1.2% of US population) and in the 5-9% of children with serious emotional disturbances, the prevalence of BPD is unknown, in 1990, BPD in established market economies resulted in 1.7 million years of lost healthy life due to premature death or disability, third only to major depression and schizophrenia. About 15% of patients with BPD commit suicide. The proportion of the NIMH dollar that goes to support research in BPD is less than expected by NIMH leadership, and there are no NIMH-funded BPD research centers. These data suggest there exists an urgent need for an NIMH research center dedicated to BPD research across the life cycle. The proposed Center addresses many of the recommendations in the 1999 "Bridging Science and Services" report by focusing on the utilization of novel longitudinal study designs in complex comorbid groups of patients with BPD from ages 5 through the end of life, as well as by focusing on function and disability, not just symptom improvement. The scientific theme of this Center will be conduct of studies designed to "improve clinical outcomes in underserved population of BPD, including those receiving care within community mental health centers (CMHC), children and adolescents, and adults currently abusing alcohol and/or drugs. The pilot projects include: 1) a single-center psychosocial intervention study designed to develop an efficient and practical way of improving treatment adherence in 166 adults with BPD in a CMHC, 2) a single-center child services project intended to improve the early and accurate recognition of BPD in 615 children and adolescents evaluated at a CMHC, and 3) a six-month, two-center, double-blind, parallel-group comparison of two regimens of combination therapy (lithium/divalproex/lamotrigine versus lithium/divalproex/placebo) for the acute and continuation outpatient management of 90 adult patients with rapid cycling BPD comorbid with alcohol, cannabis, and/or cocaine abuse/dependence at Case Western Reserve University/University Hospitals of Cleveland and a CMHC. This application will be used to build and maintain a network of sites to conduct clinical trials research that concurrently addresses issues of efficacy and effectiveness in BPD across the life cycle. This Developing Center application will be used to develop research partnerships with community settings and grow ongoing relationships, and is intended to lead to an Advanced Center submission in five years.

描述（由申请人提供）：双相情感障碍（BPD）至少影响230万18岁及以上的美国成年人（占美国人群的1.2％），而在5-9％的患有严重情绪障碍的儿童中，BPD的流行尚不清楚，1990年，BPD在1990年，BPD在既定的市场经济体中造成了170万年的健康生活，这使得健康的死亡人数丧失了，使得大不了不多的人数，这使得大不了不多。 BPD患者中约有15％自杀。支持BPD研究的NIMH美元的比例远低于NIMH领导层的预期，并且没有NIMH资助的BPD研究中心。这些数据表明，迫切需要在整个生命周期中致力于BPD研究的NIMH研究中心。拟议的中心通过着重于使用新颖的纵向研究设计，以5岁到生命年代末期的BPD患者的使用，并专注于功能和残疾，而不仅仅是症状改善，探讨了1999年“桥接科学与服务”报告中的许多建议。该中心的科学主题将是旨在“改善BPD服务不足的人群的临床结果，包括在社区心理健康中心（CMHC），儿童和青少年以及目前滥用酒精和/或药物的成年人的临床结果。飞行员项目包括：1），包括：1）一项针对16个centeral练习的方法，以改进一项良好的态度，以改进实践的方法，以进行实践，并在实践中进行了良好的态度，该方法旨在进行实践，以进行实践，以进行实践锻炼，以进行实践锻炼，以进行效果，以进行效率研究，以进行效率研究，以进行实用的锻炼方法，该研究旨在进行良好的治疗方法，该研究旨在进行良好的治疗方法。 CMHC, 2) a single-center child services project intended to improve the early and accurate recognition of BPD in 615 children and adolescents evaluated at a CMHC, and 3) a six-month, two-center, double-blind, parallel-group comparison of two regimens of combination therapy (lithium/divalproex/lamotrigine versus lithium/divalproex/placebo) for the Case Western Reserve University/Cleveland的Case Western Reserve University/University Hospitals of Cleveland和CMHC的90例快速骑自行车BPD合并症的成年患者的急性和延续门诊治疗。该应用程序将用于构建和维护一个网站网络，以进行临床试验研究，并同时解决整个生命周期中BPD的功效和有效性问题。该开发中心应用程序将用于建立具有社区环境并发展持续关系的研究合作伙伴关系，并旨在在五年内导致高级中心提交。