GHB: sympathomimetic actions of a CNS depressant

GHB：中枢神经系统抑制剂的拟交感神经作用

• 批准号: 6792348
• 负责人: ALISSA R HICKS
• 金额: $ 2.22万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-02 至 2004-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6792348
• 关键词: GABA receptor; adrenergic agents; blood pressure; cardiovascular pharmacology; central nervous system depressants; consciousness; drug abuse; drug tolerance; electroencephalography; electrophysiology; gamma hydroxybutyrate; heart rate; histology; intravenous administration; laboratory rat; neuropharmacology; pharmacokinetics; predoctoral investigator; psychopharmacology; sympathetic nervous system; telemetry

DESCRIPTION (provided by applicant): Although typically thought of as a CNS depressant, our data along with that of others show that GHB has significant sympathomimetic cardiovascular properties. The mechanisms mediating the cardiovascular responses elicited by GHB are largely unknown. This lack of knowledge is significant given the increasing recreational use of GHB and the recent interest in its therapeutic use. The proposed studies employ a variety of techniques including radio telemetry, conscious nerve recording and state-of-the-art signal analysis techniques such as coherence analysis to characterize the cardiovascular responses elicited by GHB in conscious rats. Acute studies will 1) characterize the mean arterial pressure and heart rate responses elicited by the i.v. administration of GHB 2) determine the role of GHB and GABAb receptors in mediating the cardiovascular responses elicited by GHB and, 3) assess the potential for GHB to increase sympathetic outflow by activating forebrain sympathetic pathways. Chronic studies will, for the first time, characterize the cardiovascular responses elicited by the chronic administration of GHB and assess its potential to produce cardiac toxicity.

描述（由申请人提供）： 尽管通常认为是CNS抑制剂，但我们的数据与其他数据表明GHB具有显着的交感神经性心血管特性。 GHB引起的心血管反应的介导的机制在很大程度上尚不清楚。鉴于GHB的娱乐使用及其治疗用途的最新兴趣，这种知识的缺乏意义重大。拟议的研究采用了多种技术，包括射电遥测，有意识的神经记录和最先进的信号分析技术，例如相干分析，以表征GHB在有意识的大鼠中引起的心血管反应。急性研究将为1）表征静脉内引起的平均动脉压和心率反应。 GHB的给药2）确定GHB和GABAB受体在介导GHB引起的心血管反应中的作用，以及3）评估GHB通过激活前脑交感神经途径增加交感神经流出的潜力。长期研究将首次表征GHB长期给药引起的心血管反应，并评估其产生心脏毒性的潜力。

项目成果

Mechanisms underlying the sympathomimetic cardiovascular responses elicited by gamma-hydroxybutyrate.

γ-羟基丁酸引起的拟交感神经心血管反应的机制。

• DOI: 10.1097/00005344-200412000-00002
• 发表时间: 2004
• 期刊: Journal of cardiovascular pharmacology
• 影响因子: 3
• 作者: Hicks,AlissaR;Kapusta,DanielR;Varner,KurtJ
• 通讯作者: Varner,KurtJ