Cocaine and Sucrose Cross-Sensitization in Rats

大鼠中可卡因和蔗糖的交叉过敏

• 批准号: 6836338
• 负责人: Emily D. Klein
• 金额: $ 2.35万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-07 至 2006-09-06
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6836338
• 关键词: behavioral /social science research tag; behavioral habituation /sensitization; chordate locomotion; cocaine; comorbidity; conditioning; craving; cues; eating disorders; laboratory rat; limbic system; neurochemistry; neuropharmacology; nutrient intake activity; predoctoral investigator; psychopharmacology; reinforcer; substance abuse related behavior; substance abuse related disorder; sucrose

DESCRIPTION (provided by applicant): Because food and drugs activate some of the same areas of the brain, it is hypothesized that the common ability to activate the mesolimbic dopamine system may underlie the observed relationship between substance abuse and eating disorders. The proposed experiments are based on a review of current literature and research in our laboratory that shows that rats previously exposed to cocaine demonstrate faster latencies to complete sessions on a fixed-ratio (FR) 30 schedule of reinforcement for sucrose than rats exposed to saline. It is hypothesized that exposure to cocaine sensitizes rats to the rewarding properties of sucrose and vice-versa. The first four proposed experiments will explore how previous cocaine exposure increases the value of sucrose as measured by an increased willingness to work for sucrose reward (Experiment 1) and increased consumption of sucrose (Experiments 2 & 3). Experiments 4 and 5 will examine whether exposure to sucrose produces cross-sensitization to cocaine. The findings of these experiments are intended to increase current understanding of how drug use affects the rewarding properties of natural reinforcers and how previous experience with natural reinforcers affects subsequent drug reward.

描述（由申请人提供）： 由于食物和药物会激活大脑的某些相同区域，因此推测激活中边缘多巴胺系统的共同能力可能是所观察到的药物滥用和饮食失调之间关系的基础。拟议的实验基于对我们实验室当前文献和研究的回顾，该研究表明，与接触盐水的大鼠相比，先前接触可卡因的大鼠在完成固定比例 (FR) 30 蔗糖强化方案的潜伏期更快。据推测，接触可卡因会使老鼠对蔗糖的有益特性敏感，反之亦然。提出的前四个实验将探讨以前的可卡因暴露如何增加蔗糖的价值，通过增加为蔗糖奖励而工作的意愿（实验 1）和增加蔗糖的消耗（实验 2 和 3）来衡量。实验 4 和 5 将检查接触蔗糖是否会产生对可卡因的交叉过敏。这些实验的结果旨在增加目前对药物使用如何影响天然强化物的奖励特性以及先前使用天然强化物的经验如何影响后续药物奖励的理解。