Bio-Inspired Synthesis and Assembly of Nanocrystals

纳米晶体的仿生合成和组装

• 批准号: 6818098
• 负责人: LARA A ESTROFF
• 金额: $ 3.75万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-08 至 2005-07-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6818098
• 关键词: biomaterial development /preparation; biophysics; crystallization; nanotechnology; postdoctoral investigator; surface property; surfactant

DESCRIPTION (provided by applicant): A bio-inspired approach will be used to design multi-valent surfactants which, based upon molecular recognition, will control the morphology, size distribution and ordered assembly of nanocrystals. A two-fold strategy will be used to form assemblies that have applications in biological imaging and controlled drug delivery. The bottom-up growth of specific crystalline morphologies will be accomplished using molecules designed to both recognize and attach to specific crystallographic faces. The systematic evaluation of a series of additives will produce a better mechanistic understanding of the molecular recognition events at the crystalline surface that lead to morphological control of nanocrystals. The same molecules will be used to direct the formation of ordered arrays in one-, two- and/or three-dimensions via supramolecular assembly of the functionality attached to selected faces. This approach to controlling nanocrystal morphology and assembly addresses many of the existing challenges in this field. For example, the ability to target functionality to specific faces will allow the synthesis of bifunctional nanocrystals that can be targeted to specific tissues as well as deliver a drug. Synthesis will also provide a means of specifically functionalizing symmetry related faces with molecular building blocks designed to promote aggregation in non-close-packed geometries. These aggregates can then be used for the controlled release of drugs.

描述（由申请人提供）：一种由生物启发的方法用于设计多价表面活性剂，基于分子识别，将控制纳米晶体的形态，尺寸分布和有序组装。将使用两倍的策略来形成在生物成像和受控药物输送中应用的组件。特定晶体形态的自下而上的生长将使用旨在识别和附着在特定晶体学面上的分子来实现。对一系列添加剂的系统评估将对晶体表面的分子识别事件产生更好的机械理解，从而导致纳米晶体的形态控制。相同的分子将用于通过连接到选定面的功能的超分子组件以一，二和/或三维为单位，两维的有序阵列形成。控制纳米晶形态和组装的方法解决了该领域的许多现有挑战。例如，将功能靶向特定面部的能力将允许合成双功能纳米晶体，这些纳米晶体可以靶向特定的组织并输送药物。合成还将提供一种与旨在促进非紧密包装几何形状聚集的分子构建块特异性化对称面孔的方法。然后可以将这些聚集体用于药物的控制释放。

项目成果

A non-chromatographic method for the purification of a bivalently active monoclonal IgG antibody from biological fluids.

• DOI: 10.1021/ja9023836
• 发表时间: 2009-07-08
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Bilgicer, Basar;Thomas, Samuel W., III;Shaw, Bryan F.;Kaufman, George K.;Krishnamurthy, Vijay. M.;Estroff, Lara A.;Yang, Jerry;Whitesides, George M.
• 通讯作者: Whitesides, George M.