BMP Signaling in Kidney Epithelial Cells

肾上皮细胞中的 BMP 信号转导

• 批准号: 6835925
• 负责人: JODIE L BABITT
• 金额: $ 5.25万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6835925
• 关键词: SDS polyacrylamide gel electrophoresis; biological signal transduction; bone morphogenetic proteins; gene expression; kidney cell; laboratory rat; membrane proteins; postdoctoral investigator; renal ischemia /hypoxia; transforming growth factors; western blottings

DESCRIPTION (provided by applicant): Bone morphogenic proteins (BMPs) are members of the transforming growth factor (TGF) beta super family of growth factors that regulate many physiologic and pathyphysiologic processes in the kidney including nephrogenesis, response to injury, and repair. Although their precise role in the kidney is still not fully understood, BMPs appear be protective against renal injury to a variety of insults including ischemia, obstruction, and diabetes mellitus. Dragon is a novel GPI-anchored membrane protein, which has recently been identified. Preliminary data will be presented which demonstrates that Dragon is involved in BMP signaling, and that Dragon is expressed in the kidney in renal tubular epithelial cells which are relatively protected against ischemic injury. This proposal will investigate further the precise role of Dragon in BMP signaling and elucidate the molecular and cellular mechanisms involved. Proposed experiments will also begin to examine the functional significance of Dragon expression in the kidney in relation to ischemic injury and repair.

描述（由申请人提供）：骨形态发生蛋白（BMP）是转化生长因子（TGF）beta超级生长因子的成员，它们调节了肾脏中许多生理和病态生理过程，包括肾脏发生，对损伤的反应和修复。尽管它们在肾脏中的确切作用仍未完全了解，但BMP似乎是防止肾脏损伤对包括缺血，阻塞和糖尿病在内的各种侮辱的肾脏损伤。 Dragon是一种新型的GPI锚定膜蛋白，最近已被鉴定出来。将提供初步数据，该数据表明龙与BMP信号传导有关，并且龙在肾小管上皮细胞中的肾脏表达，这些细胞相对保护，这些细胞受到相对保护的缺血性损伤。该建议将进一步研究龙在BMP信号传导中的确切作用，并阐明所涉及的分子和细胞机制。提出的实验还将开始检查龙在肾脏在缺血性损伤和修复方面的功能意义。