Silacyclopropanes: Building Blocks for Organic Synthesis

硅杂环丙烷：有机合成的基础材料

• 批准号: 6829999
• 负责人: Zulimar Nevarez
• 金额: $ 3.05万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-30 至 2007-10-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6829999
• 关键词: allyl compound; chemical group; chemical synthesis; chemical transfer reaction; cyclic compound; cyclopropanes; ethers; organic chemicals; organosilicon compound; predoctoral investigator

DESCRIPTION (provided by applicant): The proposal describes current studies towards increasing the functional group tolerance of metal-catalyzed reactions of cyclohexylsilacyclopropane. Specific objectives that I intend to address are: to develop new siliranes from allylic ethers containing an adjacent stereocenter, to study the diastereoselectivity of these unreadily available siliranes in silacyclopropanation reactions, to understand the reaction mechanisms by which they proceed, and to expand the reactions of silacyclopropanes to synthetic applications. With the knowledge obtained from allylic ethers, I intend to extend the reaction to allylic epoxides. This would allow me to generate an oxasilacyclohexene derivative that can also be further functionalized. Other functionalities such as imines will be evaluated as well and the silaaziridines generated will also be explored as potential intermediates for organic synthesis.

描述（由申请人提供）：该提案描述了当前针对提高环己基硅杂环丙烷金属催化反应的官能团耐受性的研究。我打算解决的具体目标是：从含有相邻立构中心的烯丙醚开发新的硅烷，研究这些不易获得的硅烷在硅杂环丙烷化反应中的非对映选择性，了解它们进行的反应机制，并扩展以下反应：硅杂环丙烷的合成应用。凭借从烯丙基醚获得的知识，我打算将反应扩展到烯丙基环氧化物。这将使我能够生成也可以进一步功能化的氧杂硅杂环己烯衍生物。亚胺等其他功能也将得到评估，生成的硅氮丙啶也将被探索作为有机合成的潜在中间体。