Anxiety sensitivity taxon and panic vulnerability

焦虑敏感性分类群和恐慌脆弱性

• 批准号: 6882956
• 负责人: AMIT BERNSTEIN
• 金额: $ 3.75万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2006-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6882956
• 关键词: anxiety; behavior prediction; behavior test; behavioral /social science research tag; clinical research; disease /disorder proneness /risk; fear; human subject; interview; mental health epidemiology; model design /development; panic disorder; personality; predoctoral investigator; psychological models; psychometrics; psychopathology; psychophysiology

DESCRIPTION (provided by applicant): The proposed study examines the association between a taxometrically-derived anxiety sensitivity latent class variable (i.e., taxon) and vulnerability to panic psychopathology, indexed via panic-relevant responding to a well-established 10% carbon dioxide-enriched air (CO2) biological challenge, in a sample of 160 nonclinical college student participants. The main purposes of the proposed research are to (1) test the incremental predictive validity of the anxiety sensitivity taxon with respect to vulnerability for panic-relevant responding after parsing out the effect of other theoretically-relevant risk factors, and to (2) test whether a novel categorical model of anxiety sensitivity offers enhanced explanatory power relative to the pre-existing dimensional model. The proposed research is significant because it will help the field better understand cognitive vulnerability for panic-related problems and offers important clinically-relevant implications for the prevention/treatment of panic disorder. Moreover, the proposed project is innovative because it represents the first attempt to apply taxometric procedures to the experimental psychopathology study of panic vulnerability using a well-established biological challenge paradigm.

描述（由申请人提供）：拟议的研究检查了出血式衍生的焦虑敏感性潜在的class变量（即分类单元）与恐慌心理病理学的脆弱性，通过恐慌与恐慌相关的响应，以响应良好的10％二氧化碳 - 二氧化碳 - 二氧化碳 - 在160名非临床大学学生参与者样本中，富含空气（CO2）生物学挑战。拟议的研究的主要目的是（1）测试焦虑敏感性分类群在解析其他理论上与其他相关危险因素的影响之后对恐慌相关响应的脆弱性的增量预测有效性，以及（2）测试相对于先前存在的维度模型，一种新型的焦虑敏感性分类模型是否具有增强的解释能力。拟议的研究很重要，因为它将帮助该领域更好地理解与恐慌有关的问题的认知脆弱性，并为预防/治疗恐慌症提供重要的临床意义。此外，拟议的项目具有创新性，因为它代表了使用良好的生物学挑战范式对恐慌脆弱性的实验性心理病理学研究的首次尝试。