Training and Diastolic Function in Postmenopausal Women

绝经后妇女的训练和舒张功能

• 批准号: 6808920
• 负责人: STEVEN N. BLAIR
• 金额: $ 15.2万
• 依托单位: COOPER INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6808920
• 关键词: body weight; cardiovascular disorder prevention; cardiovascular disorder risk; clinical research; congestive heart failure; dosage; echocardiography; exercise; female; heart contraction; heart ventricle; human subject; human therapy evaluation; hypertension; longitudinal human study; morphology; obesity; patient oriented research; postmenopause; ultrasound blood flow measurement; women' s health

DESCRIPTION (provided by applicant): Congestive heart failure (CHF) has become the number one reason for hospitalization in the United States. Women are more commonly hospitalized than men for this condition (in 1998, 540,000 women compared with 438,000 men). Diastolic dysfunction is becoming increasingly recognized as a significant factor in the etiology of CHF. Of the total affected population, 70% of patients with diastolic heart failure are female, with a majority being elderly. There is currently no effective pharmacological therapy for the treatment of diastolic function. With the cross-sectional studies and limited training trials (men only) supporting the hypothesis that exercise may improve diastolic function, there is a need for more properly controlled and adequately powered studies examining the effect of exercise training on diastolic function, particularly in populations at high risk for CHF such as sedentary, postmenopausal women with elevated blood pressure. The proposed study is a prospective ancillary study to the NHLBI Dose-Response to Exercise in Women (DREW) study. DREW started in January 2001. In DREW, 450 overweight, sedentary, postmenopausal women will be randomly assigned either to a non-exercise control group or to 1 of 3 exercise groups at 50, 100, and 150%, respectively, of the consensus public health recommendation for weekly physical activity (exercise). Exercising women perform supervised exercise for 6 months at our center. The DREW study will evaluate the dose-response of exercise training in regard to changes in multiple cardiac risk factors. We propose to measure diastolic function in a sub-set of this study population to examine the dose-response relation between changes in physical activity (and fitness) and diastolic function. We anticipate performing baseline and follow-up measurement of diastolic function in a total of 215 women, which will include approximately 50 women per exercise group. This study represents a unique, timely, and efficient opportunity to quickly explore the relation between diastolic function and physical activity in postmenopausal women.

描述（由申请人提供）：充血性心力衰竭（CHF）已成为美国住院的第一大原因。女性比男性更常因这种情况住院（1998 年，女性为 540,000 人，男性为 438,000 人）。人们越来越认识到舒张功能障碍是 CHF 病因学的一个重要因素。在受影响的总人口中，70%的舒张性心力衰竭患者是女性，其中大多数是老年人。目前尚无有效的药物疗法来治疗舒张功能。由于横断面研究和有限的训练试验（仅限男性）支持运动可以改善舒张功能的假设，因此需要进行更适当控制和充分有力的研究来检验运动训练对舒张功能的影响，特别是在以下人群中：慢性心力衰竭的高风险人群，例如久坐、血压升高的绝经后妇女。拟议的研究是 NHLBI 女性运动剂量反应 (DREW) 研究的一项前瞻性辅助研究。 DREW 于 2001 年 1 月开始。在 DREW 中，450 名超重、久坐、绝经后妇女将被随机分配到非运动对照组或 3 个运动组中的一组，分别占共识公众的 50%、100% 和 150%每周身体活动（锻炼）的健康建议。锻炼的女性在我们中心进行为期 6 个月的监督锻炼。 DREW 研究将评估运动训练对多种心脏危险因素变化的剂量反应。我们建议测量该研究人群的一个子集的舒张功能，以检查体力活动（和健身）变化与舒张功能之间的剂量反应关系。我们预计将对总共 215 名女性进行舒张功能基线和后续测量，其中每个运动组大约有 50 名女性。这项研究为快速探索绝经后女性舒张功能与身体活动之间的关系提供了一个独特、及时和有效的机会。