Percutaneous Respiratory Assist Catheter

经皮呼吸辅助导管

• 批准号: 6728288
• 负责人: William J. Federspiel
• 金额: $ 40万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6728288
• 关键词: aortic balloon pump; biomaterial compatibility; biomedical equipment development; blood oxygenator; carbon dioxide; catheterization; computer simulation; cow; electron microscopy; hemodynamics; hemolysis; hollow fiber separation technique; hypercapnia; implant; nonhuman therapy evaluation; postmortem; respirators; respiratory disease /disorder therapy; respiratory therapy; transposon /insertion element

The objective of this proposal is to develop a percutaneous respiratory assist catheter (PRAC) that can be inserted into the venous system to provide supplemental breathing support, independent of the lungs, for patients requiring short- term (less than 1-2 weeks) respiratory assistance. The PRAC will be designed for percutaneous insertion into a peripheral vein and placement in the central venous system, where it will be exposed to all the blood returning to the heart. The PRAC will incorporate a cylindrical bundle of microporous hollow fiber membranes woven as a fabric that is wrapped around a balloon. The balloon is pulsed with helium and enhances gas exchange by pumping blood past the hollow fibers at velocities much greater than would otherwise exist in the vena cava. The specific aims of the project are to: 1. Fabricate candidate PRAC devices with insertional diameters of 25-28 Fr (8-9 mm) and evaluate the functional mass transfer characteristics in an in-vitro test loop. We will establish how the gas exchange performance of the PRAC depends on key operating and design parameters. 2. Evaluate and optimize balloon pulsation in the PRAC to improve gas exchange. We will principally explore changes in balloon geometry and balloon pulsation mode, and we will use flow visualization, local gas tension measurements, and computational simulations to help guide our design development. 3. Perform acute calf implants of the PRAC to assess the gas exchange functionality in-situ and any adverse anatomical, physiological and biocompatibility effects associated with short- term implantation. We will also evaluate the hemolysis potential of candidate PRAC designs in-vitro using bovine blood in a bench flow loop. Our target is a percutaneous assist catheter that can provide 75- 85 ml/min of extrapulmonary CO2 removal at normocapnia and that could be used as an adjuvant or replacement to existing therapy for patients with acute lung failure (ARDS, pneumonia) or acute on chronic lung failure (COPD with exacerbation).

该提案的目的是开发经皮呼吸辅助导管（PRAC），可以将其插入静脉系统中，以提供与需要短期（小于1-2周）呼吸辅助的患者提供补充呼吸支持，独立于肺部。 PRAC将设计用于经皮插入周围静脉并放置在中央静脉系统中，并将其暴露于所有返回心脏的血液中。 PRAC将结合一个微孔空心纤维膜的圆柱捆，作为包裹在气球上的织物。气球用氦气脉冲，并通过将血液泵入空心纤维的速度远比静脉腔中的速度要大得多，从而增强气体交换。 该项目的具体目的是：1。插入直径为25-28 FR（8-9毫米）的候选PRAC设备，并评估Vitro测试环中的功能传质特性。 我们将确定PRAC的气体交换性能如何取决于关键操作和设计参数。 2。评估和优化PRAC中的气球脉动以改善气体交换。 我们将主要探索气球几何形状和气球脉动模式的变化，我们将使用流动可视化，本地气体张力测量和计算模拟来帮助指导我们的设计开发。 3.执行PRAC的急性小腿植入物，以评估原位的气体交换功能以及与短期植入相关的任何不良解剖，生理和生物相容性效应。 我们还将在台式流环中使用牛血液中候选PRAC设计的溶血潜力。我们的目标是经皮辅助导管，可以在正常核心时提供75-85 ml/min的肺外二氧化碳去除，并且可以用作急性肺衰竭（ARDS，肺炎）患者的辅助或替代治疗的辅助疗法，或者是慢性肺衰竭（copd and apaceCerbation）的急性。