Prenatal set point for adult blood pressure

成人血压的产前设定点

• 批准号: 6595222
• 负责人: JOB J. FABER
• 金额: $ 31.28万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6595222
• 关键词: angiotensin II; blood chemistry; blood pressure; cardiac output; embryo /fetus; embryo /fetus disorder; embryo /fetus surgery; glomerular filtration rate; heart; hypertension; kidney; mature animal; morphology; newborn animals; pathologic process; pulmonary hypertension; radioimmunoassay; renin; renin angiotensin system; sheep; ventricular hypertrophy

Late gestation fetal sheep will be treated to create systemic and pulmonary arterial hypertensions. One group will have high circulating angiotensin-II levels. There will be two normotensive control groups, one with normal and one with low angiotensin-II. The animals will be studied as fetuses, as newborns and as young adults. Circulatory measurements will include arterial pressures, right and left atrial pressures and cardiac outputs. We will also make plasma renin activity/renal ar6terial pressure response curves and measurements of glomerular filtration rates. Analytical measurements will include plasma renin activities, circulating angiotensin-II levels, catecholamines, plasma protein and blood hemoglobin concentrations, blood gases, osmolalities and electrolytes. Coronary pressure-flow relations will be determined under anesthesia with and without chemical dilation by means of adenosine infusions to determine coronary reserve. The animals will be killed for structural studies of heart and kidney. It is anticipated that prenatal hypertensions will produce lasting circulatory abnormalities later in life.

妊娠晚期胎羊将接受治疗以产生全身动脉高压和肺动脉高压。一组的循环血管紧张素-II 水平较高。将有两个血压正常的对照组，一组为正常血压，另一组为低血管紧张素-II。这些动物将在胎儿、新生儿和青年时期进行研究。循环测量包括动脉压、右心房压力和左心房压力以及心输出量。我们还将制作血浆肾素活性/肾动脉压响应曲线和肾小球滤过率的测量。分析测量包括血浆肾素活性、循环血管紧张素-II 水平、儿茶酚胺、血浆蛋白和血液血红蛋白浓度、血气、渗透压和电解质。将在麻醉下通过腺苷输注确定冠状动脉压力-流量关系，并进行或不进行化学扩张，以确定冠状动脉储备。这些动物将被杀死用于心脏和肾脏的结构研究。预计产前高血压将在以后的生活中产生持久的循环异常。