Risk Factors for FASD in the Moscow Region

莫斯科地区 FASD 的危险因素

• 批准号: 6805820
• 负责人: CHRISTINA CHAMBERS
• 金额: $ 25.44万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6805820
• 关键词: Commonwealth of Independent States; alcoholic beverage consumption; chemoprevention; clinical research; cooperative study; diet therapy; dietary supplements; disease /disorder prevention /control; disease /disorder proneness /risk; dosage; early diagnosis; fetal alcohol syndrome; human pregnant subject; human subject; human therapy evaluation; infant human (0-1 year); mother /embryo /fetus nutrition; nutrition related tag; substance abuse epidemiology

DESCRIPTION (provided by applicant): Defining the range of expression, risk factors for, and incidence of FASD in children born to women who drink varying amounts of alcohol during pregnancy is of vital importance in terms of prevention, intervention and treatment. The proposed study entails a collaboration with the Moscow Region Ministry of Health to screen 26,000 pregnant women over two years. From these, 640 moderate to heavy drinkers and 640 controls will be selected for longitudinal follow-up including standardized physical exams and neurobehavioral testing of infants through twelve months of age. The specific aims of the project are: 1) To measure the birth prevalence and range of alcohol-related physical features and neurobehavioral impairment among children born to pregnant women in the Moscow Region who report consuming moderate to heavy amounts of alcohol by utilizing methods designed to permit earlier diagnosis of alcohol-related effects, and 2) To evaluate the contribution of maternal nutritional factors to increased risk for prenatal growth deficiency, neurobehavioral impairment, and alcohol-related physical features in infants prenatally exposed to moderate to heavy amounts of alcohol by conducting a randomized trial of a micronutrient supplementation intervention and measuring micronutrient levels in maternal blood. The proposed study will contribute to a better understanding of the incidence and range of FASD based on early diagnosis in a cross-cultural environment, and will for the first time specifically test a nutritional intervention that may have widespread applicability should undernutrition prove to be a modifiable risk factor for FASD.

描述（由申请人提供）：定义表达范围，危险因素和FASD的发生率在怀孕期间喝不同饮酒的妇女所生的儿童在预防，干预和治疗方面至关重要。拟议的研究需要与莫斯科地区卫生部合作，在两年内筛查26,000名孕妇。从这些过程中，将选择640名中度至重型饮酒者和640个对照，以进行纵向随访，包括在十二个月大时对婴儿进行标准化的体格检查和神经行为检查。该项目的具体目的是：1）衡量莫斯科地区孕妇在孕妇出生的儿童中与酒精相关的身体特征和神经行为障碍的范围，这些儿童报告使用旨在通过允许早期诊断与酒精相关作用的诊断来评估含有含量的营养因子的饮食量中等至大量的酒精，以评估饮酒效率的早期诊断，2）通过进行微量营养素补充干预措施的随机试验并测量产妇血液中的微量营养素水平，通过产前暴露于中度至大量酒精的婴儿中的神经行为损害和与酒精相关的物理特征。拟议的研究将有助于更好地理解基于跨文化环境中早期诊断的FASD的发病率和范围，并首次专门测试营养干预措施，该营养干预措施可能具有普遍适用性的营养措施，应证明营养不良是FASD的可修改风险因素。