Regenerative Sciences Training Program (RMI)

再生科学培训计划（RMI）

• 批准号: 6874250
• 负责人: Steven A Goldstein
• 金额: $ 55.11万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6874250
• 关键词: Chordata; bioengineering /biomedical engineering; biological signal transduction; biomaterial development /preparation; biomechanics; clinical research; computational biology; cooperative study; education evaluation /planning; extracellular matrix; health science research potential; histogenesis; interdisciplinary collaboration; medical education; model design /development; musculoskeletal system; physical model; postdoctoral investigator; predoctoral investigator; regeneration; science education; structural biology; training

DESCRIPTION (provided by applicant): This proposal seeks support for the development of a new interdisciplinary training program in Regenerative Science. Repair or regeneration of tissues can be characterized as a symphony of cellular activities often beginning with an acute inflammatory response followed by granulation tissue infiltration, recruitment, proliferation and differentiation of progenitor cells, matrix formation and organization, and eventual remodeling. The process occurs within the context of biologic and mechanical signals. While many scientists, engineers and clinicians working across numerous disciplines are dedicated to advancing the repair or regeneration of tissues and organs, they fall short in their ability to communicate, interpret, or integrate across the many core competencies that we believe are required to make substantial advances in regenerative medicine. These core competencies include: developmental biology, extracellular matrix structure and organization, bioregulatory signaling, tissue structure and function, preclinical models development, structural and computational modeling, clinical research design principles, and commercialization and regulatory parameters. This program will admit biologists, engineers and clinicians with training depth in one or more disciplines and augment their abilities by teaching them critical aspects of these core competencies through didactic and research intensive experiences. While this training program will expand to train in all organ or tissue systems in the future, its initial training will focus on musculoskeletal tissues.

描述（由申请人提供）： 该建议寻求支持开发新的跨学科培训计划。组织的修复或再生可以表征为细胞活性的交响曲，通常是从急性炎症反应开始的，然后是肉芽组织浸润，募集，增殖和分化的祖细胞的增殖和分化，基质形成和组织和组织，以及最终的重塑。该过程发生在生物学和机械信号的背景下。尽管许多在众多学科工作的科学家，工程师和临床医生致力于促进组织和器官的修复或再生，但他们的交流，解释或整合能力却缺乏我们认为在再生医学上取得重大进步所必需的许多核心能力的能力。这些核心能力包括：发育生物学，细胞外基质结构和组织，生物调节信号传导，组织结构和功能，临床前模型的发展，结构和计算建模，临床研究设计原理以及商业化和调节参数。该计划将通过一个或多个学科的培训深度招收生物学家，工程师和临床医生，并通过教导和研究密集的经验来教导这些核心竞争力的关键方面，从而增强其能力。尽管该培训计划将来将扩展到所有器官或组织系统中的训练，但其最初的训练将集中在肌肉骨骼组织上。