Digitized Transmission Electron Microscope

数字化透射电子显微镜

• 批准号: 6733811
• 负责人: PAUL Nathan MCMILLAN
• 金额: $ 23.15万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-15 至 2005-06-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6733811
• 关键词: bioimaging /biomedical imaging; biomedical device power system; biomedical equipment purchase; digital imaging; transmission electron microscopy

DESCRIPTION (provided by applicant): Funds are requested for the acquisition of a modern, digital, transmission electron microscope to be installed within the Division of Core Research Laboratories at Rhode Island Hospital (the state's largest Brown University-affiliated teaching hospital and trauma center). The Morgani Model Transmission Electron Microscope will significantly benefit the research and teaching endeavors of the twelve NIH-Funded investigators whose projects are detailed in this submission and that of Brown University campus-based investigators, as well the work of hospital-based faculty that are based at the five other Brown-affiliated hospitals which collectively comprise the Brown University School Of Medicine. We currently have a decrepit 32 year old Philips 300 transmission electron microscope. Several Major components (e.g., the high voltage supply, the mercury diffusion vacuum pump, the camera transport mechanism, and at least two lens supply modules {aka K units}) are functionally unreliable and frank failure of these and/or other elements appears imminent. We have carefully considered the technical capabilities and costs of current transmission electron microscopes. Instruments at the "low" end of their price ranges are adequate for our uses, give excellent resolution (equal to or very near high-end models) and considerable flexibility, and are well suited to the research projects in this proposal, as well as likely future projects. The Philips (FEI) model Morgani 268 is a 100 kV microscope with a conventional motorized stage with a 6 degree tilt & high-resolution digital camera system. The microscope is fully digitized, controlled by an upgradable PC that is also used for digital image capture. This is a recently introduced model in the Philips line, and is the most modern of those considered. It offers exceptional value; is designed for the "cell biology, pathology, ultrastructural molecular biology" category of users; and is well suited to our needs. Unlike models that are in the middle or near the end of their product runs, this unit is at the beginning of its production period. Consequently, the microscope will be supported by the manufacturer with service and parts further into the future than the others, giving it a longer useful life span. Therefore, due to capability, versatility, needs appropriateness, upgradability, and overall value, we have specified the Philips Morgani 268 in this funding request.

描述（由申请人提供）：需要资金购买一台现代数字透射电子显微镜，安装在罗德岛医院（该州最大的布朗大学附属教学医院和创伤中心）核心研究实验室部门内。 Morgani 型透射电子显微镜将大大有利于 12 名 NIH 资助的研究人员和布朗大学校园研究人员的研究和教学工作，以及基于医院的教职人员的工作，这些研究人员的项目在本提交中详细介绍。其他五家布朗附属医院共同组成了布朗大学医学院。我们目前有一台已使用 32 年的破旧飞利浦 300 透射电子显微镜。几个主要部件（例如，高压电源、汞扩散真空泵、相机传输机构和至少两个镜头供电模块{aka K 单元}）在功能上不可靠，并且这些和/或其他元件的明显故障似乎迫在眉睫。我们仔细考虑了当前透射电子显微镜的技术能力和成本。价格范围“低”端的仪器足以满足我们的使用，提供出色的分辨率（等于或非常接近高端型号）和相当大的灵活性，并且非常适合本提案中的研究项目，以及可能的未来项目。飞利浦 (FEI) 型号 Morgani 268 是一款 100 kV 显微镜，配有传统电动载物台、6 度倾斜和高分辨率数码相机系统。该显微镜完全数字化，由可升级的 PC 控制，该 PC 也用于数字图像捕获。这是飞利浦系列中最近推出的型号，也是所考虑的型号中最现代的型号。它具有非凡的价值；专为“细胞生物学、病理学、超微结构分子生物学”类别的用户而设计；并且非常适合我们的需求。与处于产品运行中期或接近尾声的型号不同，该装置正处于生产期的开始阶段。因此，与其他显微镜相比，制造商将在未来为显微镜提供更远的服务和零件支持，从而使其使用寿命更长。因此，由于功能、多功能性、需求适当性、可升级性和整体价值，我们在本次融资请求中指定了飞利浦 Morgani 268。