Evaluating Antimicrobial Activities of Surface Coatings

评估表面涂层的抗菌活性

• 批准号: 6834241
• 负责人: Jamil Baghdadchi
• 金额: $ 10万
• 依托单位: INNOVATIVE TECHNICAL SYSTEMS CORPORATION
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6834241
• 关键词: Bacillus subtilis; Escherichia coli; Pseudomonas aeruginosa; Staphylococcus aureus; antibacterial agents; antiinfective agents; biomaterial evaluation; biomaterial interface interaction; disinfectants; drug vehicle; physical property; rubber; silver; surface coating; surface property

DESCRIPTION (provided by applicant): Many infectious diseases are acquired through casual contact with infected individuals and environmental sources. These environments include different hospital and office surfaces, food and drug processing facilities, classrooms and meeting facilities in schools; armed forces quarters, and private homes. While routine sanitation is fairy successful, it is costly and does not offer continuous protection and more importantly, no protection against fresh contamination. Self-disinfecting surface coatings containing bound antimicrobial agents can fulfill this task. The use of antimicrobial surface coatings while not aimed at producing a totally sterile environment may serve a useful purpose in areas where a permanent and more sanitary environment is necessary. The specific aims of the proposed studies are to prepare model surface coatings, test for service utility and evaluate their antimicrobial activities toward selected broad-spectrum microorganisms. Thus, the overall objective of this research application is to evaluate the anti-microbial activities of silver impregnated surface coatings that can have commercial applications. The research will be carried out by developing series of acrylic polymer-based model latex coatings that contain antimicrobial agent. The antimicrobial activities of these coatings on the test substrates will be tested toward a selected panel of gram-positive (Staphylococcus aureus ATCC 6538, Bacillus subtilis ATCC 19659) and gram negative (Pseudomonas aeruginosa ATCC 15442 and Escherichia coli ATCC 11229) bacteria. These strains of bacteria have been used as standards for testing of disinfectant efficacy using the AOAC Use-Dilution Methods and represent common bacteria encountered in health care and food preparation facilities. The antimicrobial activity will also be evaluated after exposing coated specimens to a wide variety of environmental conditions. The broader and long-term objectives are to develop economical and user-friendly self-disinfecting coatings that can be effective under variety of environmental conditions toward broader strain of bacteria.

描述（由申请人提供）：许多传染病是通过与受感染的个人和环境来源的随意接触而获得的。这些环境包括不同的医院和办公室，食品和药物处理设施，教室和学校的会议设施；武装部队区域和私人住宅。尽管常规卫生是童话般的成功，但它是昂贵的，没有提供持续的保护，更重要的是，没有保护新鲜污染。 含有结合抗微生物剂的自我感染的表面涂层可以完成此任务。使用抗菌表面涂层的使用虽然不是旨在产生完全无菌的环境，这可能在需要永久性和更卫生环境的地区有用。 拟议研究的具体目的是准备模型表面涂层，测试服务实用程序，并评估其对选定的广谱微生物的抗菌活性。因此，本研究应用的总体目的是评估可以具有商业应用的银色浸渍表面涂层的抗菌活性。这项研究将通过开发一系列含有抗菌剂的基于丙烯酸聚合物的乳胶涂层。 这些涂料在测试底物上的抗菌活性将进行测试，以朝着革兰氏阳性的选定小组（金黄色葡萄球菌ATCC 6538，枯草芽孢杆菌ATCC 19659）和革兰氏阴性（pseudomonas erigomonas aeruginosa atc​​c 15442和Escherichia Coli actcc atcc atcc atcc 11229））进行测试。这些细菌菌株已被用作使用AOAC使用稀释方法测试消毒疗效的标准，并代表在医疗保健和食物准备设施中遇到的常见细菌。在将涂层标本暴露于各种环境条件下，还将评估抗菌活性。 更广泛的长期目标是开发经济且用户友好的自我感染涂层，这些涂料在各种环境条件下可以有效，以实现更广泛的细菌菌株。