Transportable Chlorine Dioxide Sterilization System

便携式二氧化氯灭菌系统

• 批准号: 6736623
• 负责人: Stuart K Williams
• 金额: $ 10万
• 依托单位: PARE TECHNOLOGIES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2007-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6736623
• 关键词: Bacillus subtilis; antiinfective agents; bioengineering /biomedical engineering; biomaterial compatibility; biomedical equipment development; chlorine; cytotoxicity; disinfectants; iatrogenic disease; nosocomial infections; portable biomedical equipment; spores

DESCRIPTION (provided by applicant): Medical infections remain a major cause of morbidity and mortality in the United States. The proposed studies have a primary goal to develop a transportable sterilization cabinet for use in patient care facilities including hospital, clinics, physician offices and assisted living environments. Chlorine dioxide gas will be used as the sterilizing agent. A major methodological goal of this program is the development of a disposable chlorine dioxide generating system to be used with the transportable cabinet. A major advantage of the proposed system is the use of chlorine dioxide gas with its established ability to kill a wide range of microbes including bacteria, viruses, mold and fungi. Three specific aims have been developed to evaluate the feasibility of this sterilization unit. Specific Aim 1. will evaluate optimal concentrations of chlorine dioxide and treatment times necessary to provide sporicidal activity. Specific Aim 2. will evaluate the effect of CIO2 sterilization on medical instrument material characteristics. Specific Aim 3. will evaluate the efficacy of a prototype commercial sterilization unit and disposable gas generation system using reusable medical instruments as a test system. Following completion of these studies Phase II funding will be sought to optimize and commercialize a transportable sterilization unit.

描述（由申请人提供）： 医疗感染仍然是美国发病和死亡的主要原因。拟议研究的主要目标是开发一种可移动的灭菌柜，用于患者护理设施，包括医院、诊所、医生办公室和辅助生活环境。二氧化氯气体将用作消毒剂。该计划的一个主要方法目标是开发与可移动柜一起使用的一次性二氧化氯发生系统。该系统的一个主要优点是使用二氧化氯气体，其具有杀死多种微生物的能力，包括细菌、病毒、霉菌和真菌。已经制定了三个具体目标来评估该灭菌装置的可行性。 具体目标 1. 将评估二氧化氯的最佳浓度和提供杀孢子活性所需的处理时间。 具体目标 2. 将评估 CIO2 灭菌对医疗器械材料特性的影响。 具体目标 3. 将使用可重复使用的医疗器械作为测试系统来评估原型商业灭菌装置和一次性气体发生系统的功效。这些研究完成后，将寻求第二阶段资金来优化可移动灭菌装置并将其商业化。