Humoral And Cellular Tolerization Approaches Against Au*

针对 Au* 的体液和细胞耐受方法

• 批准号: 6803537
• 负责人: MASSIMO M. TRUCCO
• 金额: $ 70.59万
• 依托单位: CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6803537
• 关键词: autoimmunity; clinical research; cooperative study; human subject

DESCRIPTION (provided by applicant): After carefully evaluating the merits, potential pitfalls, concerns and failures of the strategies so far proposed to treat autoimmune diseases, it was concluded that recombinant antibody and dendritic cell-based approaches would be clinically translatable modalities with the greatest likelihood of success during treatment, combined with the least concern of deleterious side effects. Importantly, the investigators collaborating in this proposal have themselves, or are collaborating with others at the University of Pittsburgh who have exceptional expertise in these approaches. This application will provide further insights into the basic mechanisms of action of the proposed approaches, in itself a compelling rationale for their selection and evaluation. To better organize these studies, it was also concluded that an Autoimmunity Center of Excellence may represent the most appropriate "umbrella" under which to consolidate the efforts of the interested clinicians and scientists of the University of Pittsburgh. The complexity of studying and developing new therapeutic approaches to treating autoimmune diseases requires a modern, multidisciplinary research climate. The synchronization of both the expertise and the technology available among the investigators within this university who are interested in the same scientific area, i.e., autoimmunity, is necessary in order to maximize the use of all of the resources in the most cost effective and academically efficient manner. Moreover the University of Pittsburgh will greatly benefit from a forum specifically dedicated to the study of autoimmunity, where both junior and established investigators within different departments and institutions, and with interdisciplinary expertise, can be drawn together with interested clinicians so that bench-to-bedside transfer can be fostered more efficiently. In order to encourage young researchers to devote their careers to the study of autoimmune ailments, especially those that affect children, it is here proposed to build an Autoimmune Center of Excellence with the specific belief that fostering of this type of career is easier within a scientifically challenging atmosphere of collegiality and intellectual discourse. Finally, having an Autoimmunity Center of Excellence in Pittsburgh entirely dedicated to a single philosophical and scientific goal: "understanding, preventing and eventually curing autoimmune diseases" will allow the creation of new scientific leads that will form the basis for more promising clinical trials.

描述（由申请人提供）： 在仔细评估了迄今为止旨在治疗自身免疫性疾病的策略的优点，潜在的陷阱，关注和失败之后，得出的结论是，重组抗体和基于树突状的基于树状的细胞方法将是临床上可转换的方式，在治疗过程中与最不太关心的副作用相结合，对成功的可能性最大。重要的是，在此提案中合作的调查人员本人或正在与匹兹堡大学的其他人合作，他们在这些方法方面具有非凡的专业知识。该应用程序将进一步了解所提出方法的基本作用机制，这本身就是他们选择和评估的引人注目的理由。为了更好地组织这些研究，还可以得出结论，一个自身免疫性卓越中心可能代表了最合适的“伞”，以巩固匹兹堡大学感兴趣的临床医生和科学家的努力。研究和开发新的治疗方法来治疗自身免疫性疾病的复杂性需要现代的多学科研究氛围。为了以最具成本效率和学术上有效的方式最大化所有资源，必须同步该大学的研究人员之间的专业知识和技术，即自身免疫性。 此外，匹兹堡大学将从专门用于自身免疫研究的论坛中受益匪浅，在该论坛上，在不同系和机构中的初级和成熟的研究人员都可以与有兴趣的临床医生一起绘制跨学科的专业知识，因此可以与临床医生一起绘制，因此可以更有效地培养替补席上转移。为了鼓励年轻的研究人员将自己的职业生涯用于自身免疫性疾病，尤其是那些影响儿童的疾病的研究，在这里提议建立一个自身免疫性的卓越中心，具体的信念是，在科学挑战性的协会性和智力言论的氛围中，培养这种类型的职业是更容易的。最后，在匹兹堡拥有自身免疫卓越中心，完全致力于一个哲学和科学的目标：“理解，预防并最终治愈自身免疫性疾病”将允许创建新的科学领导者，这将成为更有希望的临床试验的基础。