Computer Directed Photodynamic Therapy of Prostate Ca

计算机引导前列腺钙光动力治疗

• 批准号: 6699978
• 负责人: JERZY JANKUN
• 金额: $ 28.75万
• 依托单位: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-02 至 2006-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6699978
• 关键词: computer assisted patient care; computer simulation; computer system design /evaluation; dogs; neoplasm /cancer photoradiation therapy; nonhuman therapy evaluation; photosensitizing agents; porphyrins; prostate neoplasms

DESCRIPTION (Verbatim from Applicant's Abstract): The objective of the proposal is to provide a critical body of knowledge with the ultimate goal of transferring photodynamic therapy (PDT) to the clinical arena for the treatment of prostate cancer. The widespread use of PSA test as an adjunct to digital rectal examination has led to an increase in the diagnosis of prostate cancer in its early stages. Treatment of organ confined prostatic cancer includes radical prostatectomy, radiotherapy, brachytherapy and cryosurgical ablation. Results from all these are favorable at least in terms of short outcomes. Still, with Tic disease, 30 percent of patients will have biochemical failure within 5 years of treatment. Clearly novel methods of prostate cancer treatment are needed. We want to utilize PDT as a novel approach to the treatment of prostatic cancer. PDT for prostate cancer depends on the sequestration of a PDT drug within the glandular tissue of the prostate. The photosensitizer is subsequently activated by high-energy light producing cytotoxic substances, which in turn destroy cancerous tissue. Since prostate cancer is a multi-focal disease, PDT must ablate the prostate completely. Complete ablation will depend on quantification of tissue sensitivity to a photosensitizer, precise placement of light sources in the prostate and delivery of a therapeutic light dose to the entire gland. The prostate is irregular in shape, so transurethral light delivery cannot be used for the treatment of the majority of prostate cancers. Additionally, most cancers are located in the peripheral zone of the prostate, an area unlikely to be reached by transurethrally launched light. Sources of light and their spatial distribution must be tailored to each patient. More uniform light distribution can be achieved by interstitial light irradiation. In this case, the light is delivered by diffusers placed within the substance of the prostate parallel to the urethra at a distance optimized to deliver adequate levels of light and to create the desired photodynamic effect. To achieve uniform light distribution throughout the prostate we are developing a computer program that can determine treatment effects by calculating the distribution of light energy depending on the number of light sources placed in the prostate, their position in the gland, the dimension of the prostate, and the tissue attenuation coefficient.

描述（逐字研究来自申请人的摘要）：提案的目的 是提供一个批判的知识体系，以最终的目标 将光动力疗法（PDT）转移到临床领域进行治疗 前列腺癌。 PSA测试作为数字辅助的广泛使用 直肠检查导致前列腺癌的诊断增加 在早期阶段。器官的治疗限制前列腺癌包括 根治性前列腺切除术，放射疗法，近距离放射治疗和冷冻外科消融。 所有这些的结果至少在短时间内是有利的。 尽管如此，有30％的患者将患有生化衰竭 在治疗的5年内。明显新颖的前列腺癌治疗方法 需要。我们想利用PDT作为一种新颖的方法 前列腺癌。前列腺癌的PDT取决于PDT的隔离 药物在前列腺的腺组织中。光敏剂是 随后通过产生细胞毒性物质的高能光激活， 反过来破坏了癌组织。由于前列腺癌是多焦点 疾病，PDT必须完全消除前列腺。完整的消融将取决于 关于对光敏剂的组织敏感性定量，精确的放置 前列腺中的光源和治疗光剂量的递送 整个腺体。前列腺的形状不规则，因此尿道光 分娩不能用于治疗大多数前列腺癌。 此外，大多数癌症位于前列腺的外围区域， 不太可能通过横断力发射的光线到达一个区域。来源 光及其空间分布必须针对每个患者量身定制。更多的 均匀的光分布可以通过间隙光照射来实现。 在这种情况下，光线由放置在物质中的扩散器传递 以优化的距离与尿道平行的前列腺 足够的光水平并产生所需的光动力效应。到 在整个前列腺中实现统一的光分布，我们正在开发一个 可以通过计算来确定治疗效果的计算机程序 光能的分布取决于放置的光源的数量 前列腺，它们在腺体中的位置，前列腺的尺寸以及 组织衰减系数。