COGNITIVE EFFECTS OF LUNG VOLUME REDUCTION SURGERY

肺减容手术对认知的影响

• 批准号: 6833857
• 负责人: ELIZABETH KOZORA
• 金额: $ 3.84万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-01 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6833857
• 关键词: behavioral /social science research tag; chronic obstructive pulmonary disease; clinical research; cognition; emphysema; human subject; human therapy evaluation; neuropsychological tests; neuropsychology; pneumonectomy; quality of life

The primary goal of this study is to examine the neuropsychological functioning of emphysema patients undergoing lung volume reduction surgery (MT+LVRS) compared to medical therapy alone (MT). The study will include patients at two clinical sites for the National Emphysema Treatment Trial (NETT). Enhancements of ventilation and functional capacity are expected to contribute to greater long-term improvements in utilization of oxygen in the brain, thereby leading to improvements in cognitive performance greater than those observed among patients who exercise but do not receive LVRS (Specific Aim 1). A health control group will be retested on similar neuropsychological tests in order to control for practice effects (Specific Aim 2). Although we do not expect significant differences in emotional (depression and anxiety) functioning across groups, this study will enable us to evaluate the relationship between emotional status and neuropsychological scores in the MT+ LVRS and MT groups following randomization. In addition, since major neurological events are more likely following surgery, and major neurological events affect cognitive function, we will evaluate the incidence of neurological events in our sample and will determine the degree to which neurological events are associated with cognitive function (Specific Aim 3). No studies have examined the relationship between change in cognition and improve quality of life in COPD patients following LVRS surgery, therefore, we aim to explore these associations in Specific Aim 4. We propose to compare changes following LVRS and MT by examining 84 NETT patients (42 in MT, 42 in LVRS) at three times points (baseline, post 6-10 week medical treatment MT, and 6 months post MT or LVRS randomization) using select neuropsychological, psychological, neurological and QoL tests. Forty normal controls will be tested at baseline and 6-10 weeks follow- up.

这项研究的主要目的是检查接受肺量减少手术（MT+LVR）的肺气肿患者的神经心理学功能与单独的药物治疗（MT）相比。该研究将包括在国家肺气肿治疗试验（NETT）的两个临床部位的患者。预计通风和功能能力的增强有助于更大的长期改善大脑氧利用的长期利用，从而导致认知性能的提高比在运动但未接受LVR的患者中观察到的认知能力的改善（特定目标1）。将在类似的神经心理学测试中重新测试健康控制组，以控制实践效果（特定目标2）。尽管我们期望在各组之间的情绪（抑郁和焦虑）功能上没有显着差异，但这项研究将使我们能够评估MT+ LVRS和随机分组后MT+ LVR和MT组中的情绪状况与神经心理学分数之间的关系。此外，由于手术后主要的神经系统事件更有可能，并且主要神经事件影响认知功能，因此我们将评估样本中神经系统事件的发生率，并将确定神经系统事件与认知功能相关的程度（特定目标3）。尚无研究检查LVRS手术后Cognition的变化与改善COPD患者生活质量之间的关系，因此，我们的目的是在特定目的4中探索这些关联。我们建议比较LVRS和MT之后的变化和MT的变化，以检查84名NetT患者（在6-10个星期后MT，MT，42位MT，42位MT，42个），以及MT的6-10周后MT，LV，LVS，LV，LV，MT 6-10周后，MT，LV，LVRS的42例，LV。神经心理学，心理学，神经和质量检查测试。将在基线和6-10周后进行40个正常对照。