THE BIOLOGY OF LUNG CANCER-- FDG AND FLUOROTHYMIDINE PET

肺癌的生物学--FDG和氟胸苷宠物

• 批准号: 6685859
• 负责人: HUBERT J VESSELLE
• 金额: $ 37.62万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-01-12 至 2005-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6685859
• 关键词: DNA replication; bioimaging /biomedical imaging; biomarker; cell proliferation; clinical research; deoxyglucose; flow cytometry; glucose metabolism; human subject; immunocytochemistry; lung imaging /visualization /scanning; metastasis; neoplasm /cancer classification /staging; neoplasm /cancer relapse /recurrence; neoplastic process; nonsmall cell lung cancer; outcomes research; positron emission tomography; postoperative state; preoperative state; prognosis; radiation dosage

The objective of the proposed studies is to investigate quantitative [F- 18]fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) as a measure of non-small cell lung cancer (NSCLC) aggressiveness in vivo (i.e. grading) and to make comparisons with patients' outcomes and with specimen-derived measures of cellular proliferation previously shown to predict poor outcome (S-phase fraction, Ki-67 index). We postulate that, in clinically resectable NSCLC patients, pre-operative FDG PET will show that tumors with higher FDG uptake: (a) will recur sooner after surgical resection than same stage tumors with low uptake; (b) are more likely to have mediastinal or distal metastatic disease than tumors of the same clinical stage but low uptake; (c) have higher S-phase fraction of Ki-67 scores in their resected specimen. The specific aims of the proposal are: (1) Perform whole-body pre- operative FDG PET imaging and correlate FDG uptake in primary NSCLC with outcome. FDG uptake will be quantified by the following methods that will be compared. Standardized Uptake Value (SUV) and SKM-FDGMR (FDG Metabolic Rate determined by a Simplified Kinetic Method). (2) Perform whole-body pre-operative FDG PET imaging and correlate FDG uptake (quantified as SUV and SKM-FDGMR) in primary NSCLC with disease extent as demonstrated by PET and surgical staging. (3) Correlate pre-operative FDG uptake in primary NSCLC with markers of cellular proliferation measured from the resected specimen and previously shown to predict poor outcome. Outcome will be measured by recurrence-free survival, time-to recurrence and survival. In summary, by studying NSCLC patients pre-operatively, prior to any form of chemotherapy or radiotherapy, we will gain valuable information about the biology of lung cancer, the leading cause of cancer death in the United States. By performing a biologic grading of resectable NSCLC with FDG PET, we will predict which patients will have a worse outcome. This information will allow individualized therapy.

拟议的研究的目的是研究定量[F-18]氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET），以衡量非小细胞肺癌（NSCLC）在体内的侵略性（即分级）并与比较患者的结局和标本衍生的细胞增殖量度先前证明可以预测结果不佳（S期分数，KI-67指数）。我们假设，在临床可切除的NSCLC患者中，术前的FDG PET将表明，手术切除术后FDG摄取较高的肿瘤将比同一阶段肿瘤更早复发； （b）比同一临床阶段的肿瘤更有可能患有纵隔或远端转移性疾病，但摄入率低； （c）在切除的样品中具有较高的KI-67分数S相分数。该提案的具体目的是：（1）执行全身前FDG PET成像，并将原发性NSCLC中的FDG摄取与结果相关联。 FDG摄取将通过以下方法进行量化。标准化摄取值（SUV）和SKM-FDGMR（通过简化动力学方法确定的FDG代谢率）。 （2）在原发性NSCLC中进行全身术前FDG PET成像，并将FDG摄取（定量为SUV和SKM-FDGMR），其疾病程度与PET和手术分期相关。 （3）将术前NSCLC中的术前FDG摄取与根据切除的样品测得的细胞增殖标志物相关联，并且先前显示出可预测结果不佳的结果。结果将通过无复发的生存，复发和生存来衡量。总而言之，通过在术前研究NSCLC患者，在任何形式的化学疗法或放疗之前，我们将获得有关肺癌生物学的宝贵信息，肺癌是美国癌症死亡的主要原因。通过使用FDG PET进行可切除的NSCLC的生物学分级，我们将预测哪些患者的结果将会较差。此信息将允许个性化治疗。

项目成果

Application of a neural network to improve nodal staging accuracy with 18F-FDG PET in non-small cell lung cancer.

• 发表时间: 2003-12
• 期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
• 作者: H. Vesselle;É. Turcotte;L. Wiens;D. Haynor

Lung cancer proliferation correlates with [F-18]fluorodeoxyglucose uptake by positron emission tomography.

正电子发射断层扫描显示肺癌增殖与[F-18]氟脱氧葡萄糖摄取相关。

• 发表时间: 2000
• 期刊: Clinical cancer research : an official journal of the American Association for Cancer Research
• 作者: Vesselle,H;Schmidt,RA;Pugsley,JM;Li,M;Kohlmyer,SG;Vallires,E;Wood,DE
• 通讯作者: Wood,DE

In vivo validation of 3'deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) as a proliferation imaging tracer in humans: correlation of [(18)F]FLT uptake by positron emission tomography with Ki-67 immunohistochemistry and flow cytometry in human lung tumors.

3脱氧-3-[(18)F]氟胸苷 ([(18)F]FLT) 作为人体增殖成像示踪剂的体内验证：正电子发射断层扫描 [(18)F]FLT 摄取与

• 发表时间: 2002
• 期刊: Clinical cancer research : an official journal of the American Association for Cancer Research
• 作者: Vesselle,Hubert;Grierson,John;Muzi,Mark;Pugsley,JeffreyM;Schmidt,RodneyA;Rabinowitz,Peter;Peterson,LanellM;Vallières,Eric;Wood,DouglasE
• 通讯作者: Wood,DouglasE